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Article: H5N1 virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocyte-derived macrophages

TitleH5N1 virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocyte-derived macrophages
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2012, v. 206 n. 5, p. 640-645 How to Cite?
AbstractH5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection. © The Author 2012.
Persistent Identifierhttp://hdl.handle.net/10722/179840
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYen_US
dc.contributor.authorChan, EYen_US
dc.contributor.authorKrasnoselsky, Aen_US
dc.contributor.authorPurdy, Den_US
dc.contributor.authorNavare, ATen_US
dc.contributor.authorBryan, JTen_US
dc.contributor.authorLeung, CKLen_US
dc.contributor.authorHui, KPYen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorKatze, MGen_US
dc.date.accessioned2012-12-19T10:05:21Z-
dc.date.available2012-12-19T10:05:21Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Infectious Diseases, 2012, v. 206 n. 5, p. 640-645en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/179840-
dc.description.abstractH5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection. © The Author 2012.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.titleH5N1 virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocyte-derived macrophagesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, CY: chungey@hkucc.hku.hken_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityCheung, CY=rp00404en_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/infdis/jis423en_US
dc.identifier.pmid22822004-
dc.identifier.scopuseid_2-s2.0-84864934670en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84864934670&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume206en_US
dc.identifier.issue5en_US
dc.identifier.spage640en_US
dc.identifier.epage645en_US
dc.identifier.eissn1537-6613-
dc.identifier.isiWOS:000307501800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, CY=7202061836en_US
dc.identifier.scopusauthoridChan, EY=7401994013en_US
dc.identifier.scopusauthoridKrasnoselsky, A=21741053000en_US
dc.identifier.scopusauthoridPurdy, D=7004979389en_US
dc.identifier.scopusauthoridNavare, AT=15755843000en_US
dc.identifier.scopusauthoridBryan, JT=55334824000en_US
dc.identifier.scopusauthoridLeung, CKL=44961375700en_US
dc.identifier.scopusauthoridHui, KPY=24492032000en_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridKatze, MG=7006672394en_US

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