File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Influenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferrets

TitleInfluenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferrets
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2004, v. 190 n. 9, p. 1627-1630 How to Cite?
AbstractThree type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in the ferret model, an R292K mutant of a type A (H3N2) virus was not transmitted under conditions in which the wild-type virus was transmitted. This model was used to investigate whether the E119V mutant of a type A (H3N2) virus and the H274Y mutant of a type A (H1N1) virus would be transmitted under similar circumstances. Both mutant viruses were transmitted, although the H274Y mutant required a 100-fold-higher dose for infection of donor ferrets and was transmitted more slowly than was the wild type. Both the mutant and the wild-type viruses retained their genotypic characteristics.
Persistent Identifierhttp://hdl.handle.net/10722/179822
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHerlocher, MLen_US
dc.contributor.authorTruscon, Ren_US
dc.contributor.authorElias, Sen_US
dc.contributor.authorYen, HLen_US
dc.contributor.authorRoberts, NAen_US
dc.contributor.authorOhmit, SEen_US
dc.contributor.authorMonto, ASen_US
dc.date.accessioned2012-12-19T10:05:12Z-
dc.date.available2012-12-19T10:05:12Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Infectious Diseases, 2004, v. 190 n. 9, p. 1627-1630en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/179822-
dc.description.abstractThree type A influenza viruses, each of which has a distinct neuraminidase-gene mutation and is resistant to the neuraminidase inhibitor oseltamivir, have been isolated. Previously, in the ferret model, an R292K mutant of a type A (H3N2) virus was not transmitted under conditions in which the wild-type virus was transmitted. This model was used to investigate whether the E119V mutant of a type A (H3N2) virus and the H274Y mutant of a type A (H1N1) virus would be transmitted under similar circumstances. Both mutant viruses were transmitted, although the H274Y mutant required a 100-fold-higher dose for infection of donor ferrets and was transmitted more slowly than was the wild type. Both the mutant and the wild-type viruses retained their genotypic characteristics.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAcetamides - Pharmacologyen_US
dc.subject.meshAmino Acid Substitutionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntiviral Agents - Pharmacologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDrug Resistance, Viralen_US
dc.subject.meshFerretsen_US
dc.subject.meshInfluenza A Virus - Drug Effects - Genetics - Growth & Developmenten_US
dc.subject.meshMutationen_US
dc.subject.meshNeuraminidase - Antagonists & Inhibitors - Geneticsen_US
dc.subject.meshOrthomyxoviridae Infections - Transmission - Virologyen_US
dc.subject.meshOseltamiviren_US
dc.subject.meshViral Proteins - Geneticsen_US
dc.titleInfluenza viruses resistant to the antiviral drug oseltamivir: Transmission studies in ferretsen_US
dc.typeArticleen_US
dc.identifier.emailYen, HL: hyen@hku.hken_US
dc.identifier.authorityYen, HL=rp00304en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1086/424572en_US
dc.identifier.pmid15478068-
dc.identifier.scopuseid_2-s2.0-6944227719en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-6944227719&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume190en_US
dc.identifier.issue9en_US
dc.identifier.spage1627en_US
dc.identifier.epage1630en_US
dc.identifier.isiWOS:000224303100014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHerlocher, ML=6602769387en_US
dc.identifier.scopusauthoridTruscon, R=6507370205en_US
dc.identifier.scopusauthoridElias, S=7102552434en_US
dc.identifier.scopusauthoridYen, HL=7102476668en_US
dc.identifier.scopusauthoridRoberts, NA=7202129760en_US
dc.identifier.scopusauthoridOhmit, SE=6604064670en_US
dc.identifier.scopusauthoridMonto, AS=7004552306en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats