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Article: Prenatal detection of fetal Down's syndrome from maternal plasma

TitlePrenatal detection of fetal Down's syndrome from maternal plasma
Authors
Issue Date2000
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2000, v. 356 n. 9244, p. 1819-1820 How to Cite?
AbstractFetal DNA is present in maternal plasma, and a proportion of such DNA is seen in intact fetal cells. We investigated the use of fluorescence in-situ hybridisation (FISH) techniques on maternal plasma samples. In plasma samples obtained from three women carrying fetuses affected by trisomy 21 (Down's syndrome), we identified fetal cells with three chromosome-21 signals. These results show the feasibility of non-invasive detection of fetal chromosomal aneuploidy by maternal plasma analysis.
Persistent Identifierhttp://hdl.handle.net/10722/179767
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPoon, LLMen_US
dc.contributor.authorLeung, TNen_US
dc.contributor.authorLau, TKen_US
dc.contributor.authorLo, YMDen_US
dc.date.accessioned2012-12-19T10:04:26Z-
dc.date.available2012-12-19T10:04:26Z-
dc.date.issued2000en_US
dc.identifier.citationLancet, 2000, v. 356 n. 9244, p. 1819-1820en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/179767-
dc.description.abstractFetal DNA is present in maternal plasma, and a proportion of such DNA is seen in intact fetal cells. We investigated the use of fluorescence in-situ hybridisation (FISH) techniques on maternal plasma samples. In plasma samples obtained from three women carrying fetuses affected by trisomy 21 (Down's syndrome), we identified fetal cells with three chromosome-21 signals. These results show the feasibility of non-invasive detection of fetal chromosomal aneuploidy by maternal plasma analysis.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshDown Syndrome - Diagnosis - Embryologyen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Diseases - Diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.titlePrenatal detection of fetal Down's syndrome from maternal plasmaen_US
dc.typeArticleen_US
dc.identifier.emailPoon, LLM: llmpoon@hkucc.hku.hken_US
dc.identifier.authorityPoon, LLM=rp00484en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(00)03237-2-
dc.identifier.pmid11117917-
dc.identifier.scopuseid_2-s2.0-0034715975en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034715975&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume356en_US
dc.identifier.issue9244en_US
dc.identifier.spage1819en_US
dc.identifier.epage1820en_US
dc.identifier.isiWOS:000165545700016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPoon, LLM=7005441747en_US
dc.identifier.scopusauthoridLeung, TN=7202110927en_US
dc.identifier.scopusauthoridLau, TK=24491963900en_US
dc.identifier.scopusauthoridLo, YMD=7401935391en_US

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