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Article: Antibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka

TitleAntibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lanka
Authors
Issue Date1990
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/trstmh
Citation
Transactions Of The Royal Society Of Tropical Medicine And Hygiene, 1990, v. 84 n. 1, p. 35-39 How to Cite?
AbstractAn enzyme-linked immunosorbent assay (ELISA) based on the synthetic peptide (NANP) 40 was used to characterize the sporozoite antibodies in an unusual Plasmodium falciparum outbreak in a non-malarious ara in Sri Lanka. A positive antibody response was seen in 62% of patients with their first P. falciparum illness. There was no correlation between sporozoite antibodies and the antibody against blood stages, determined by immunofluorescence assay. The majority (91%) of the patients lost the antibodies to circumsporozoite (CS) protein within one year (in the absence of re-exposure). Three patients had high levels of CS antibodies even after one year, and this persistence was related to the level of the initial antibody response. In the area of the outbreak 10% of schoolchildren had antibodies to the (NANP) 40 peptide. 21% of the 42 children with present or past overt malaria were antibody positive. Of the children with no such background, 8% were antibody positive. The corresponding seropositivity rates for asexual blood stages were 31% and 1% for the 2 groups respectively. It is concluded that (NANP) 40 ELISA is potentially a valuable tool in sero-epidemiology, particularly in situations of seasonal transmission and recurrences due to drug resistance.
Persistent Identifierhttp://hdl.handle.net/10722/179737
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.939

 

DC FieldValueLanguage
dc.contributor.authorDe Wijesundera, SMen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorAriyaratne, YGen_US
dc.contributor.authorVerdini, ASen_US
dc.contributor.authorPessi, Aen_US
dc.contributor.authorDel Giudice, Gen_US
dc.date.accessioned2012-12-19T10:04:11Z-
dc.date.available2012-12-19T10:04:11Z-
dc.date.issued1990en_US
dc.identifier.citationTransactions Of The Royal Society Of Tropical Medicine And Hygiene, 1990, v. 84 n. 1, p. 35-39en_US
dc.identifier.issn0035-9203en_US
dc.identifier.urihttp://hdl.handle.net/10722/179737-
dc.description.abstractAn enzyme-linked immunosorbent assay (ELISA) based on the synthetic peptide (NANP) 40 was used to characterize the sporozoite antibodies in an unusual Plasmodium falciparum outbreak in a non-malarious ara in Sri Lanka. A positive antibody response was seen in 62% of patients with their first P. falciparum illness. There was no correlation between sporozoite antibodies and the antibody against blood stages, determined by immunofluorescence assay. The majority (91%) of the patients lost the antibodies to circumsporozoite (CS) protein within one year (in the absence of re-exposure). Three patients had high levels of CS antibodies even after one year, and this persistence was related to the level of the initial antibody response. In the area of the outbreak 10% of schoolchildren had antibodies to the (NANP) 40 peptide. 21% of the 42 children with present or past overt malaria were antibody positive. Of the children with no such background, 8% were antibody positive. The corresponding seropositivity rates for asexual blood stages were 31% and 1% for the 2 groups respectively. It is concluded that (NANP) 40 ELISA is potentially a valuable tool in sero-epidemiology, particularly in situations of seasonal transmission and recurrences due to drug resistance.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/trstmhen_US
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygieneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Protozoan - Analysis - Immunologyen_US
dc.subject.meshAntibody Formationen_US
dc.subject.meshApicomplexa - Immunologyen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria - Epidemiology - Immunologyen_US
dc.subject.meshPlasmodium Falciparum - Immunologyen_US
dc.subject.meshSri Lankaen_US
dc.titleAntibodies to Plasmodium falciparum sporozoites following a malarial outbreak in a non-endemic area of Sri Lankaen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0035-9203(90)90372-Len_US
dc.identifier.pmid2111943-
dc.identifier.scopuseid_2-s2.0-0025176818en_US
dc.identifier.volume84en_US
dc.identifier.issue1en_US
dc.identifier.spage35en_US
dc.identifier.epage39en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDe Wijesundera, SM=6508111405en_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridAriyaratne, YG=11238780000en_US
dc.identifier.scopusauthoridVerdini, AS=7004002171en_US
dc.identifier.scopusauthoridPessi, A=7005806554en_US
dc.identifier.scopusauthoridDel Giudice, G=7006629475en_US

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