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Article: Monoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria

TitleMonoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malaria
Authors
Issue Date1988
PublisherAmerican Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/
Citation
American Journal Of Tropical Medicine And Hygiene, 1988, v. 39 n. 1, p. 26-32 How to Cite?
AbstractAntibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.
Persistent Identifierhttp://hdl.handle.net/10722/179734
ISSN
2015 Impact Factor: 2.453
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorPremawansa, Sen_US
dc.contributor.authorRanawaka, MBRen_US
dc.contributor.authorUdagama, PVen_US
dc.contributor.authorMunasinghe, YDen_US
dc.contributor.authorNanayakkara, MVen_US
dc.contributor.authorGamage, CPen_US
dc.contributor.authorCarter, Ren_US
dc.contributor.authorDavid, PHen_US
dc.contributor.authorMendis, KNen_US
dc.date.accessioned2012-12-19T10:04:09Z-
dc.date.available2012-12-19T10:04:09Z-
dc.date.issued1988en_US
dc.identifier.citationAmerican Journal Of Tropical Medicine And Hygiene, 1988, v. 39 n. 1, p. 26-32en_US
dc.identifier.issn0002-9637en_US
dc.identifier.urihttp://hdl.handle.net/10722/179734-
dc.description.abstractAntibodies against gametes of the malarial parasite inhibit the development of the parasite in the mosquito and curtail the transmission of malaria. We now report that a monoclonal antibody against gametes of the human malaria pathogen Plasmodium vivax and antibodies induced during natural infections of P. vivax in humans which suppress infectivity of the parasites to the vector at high concentrations can, at lower concentrations, have the opposite effect and enhance the level of malaria infection in the mosquitoes. Infectivity enhancing effects of up to 12-fold were demonstrated when a transmission blocking monoclonal antibody and immune human sera were diluted, in some undiluted immune human sera, and in the sera of vivax malaria patients during convalescence after drug cure.en_US
dc.languageengen_US
dc.publisherAmerican Society of Tropical Medicine and Hygiene. The Journal's web site is located at http://www.ajtmh.org/en_US
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygieneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnopheles - Parasitologyen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntibodies, Protozoan - Immunologyen_US
dc.subject.meshBinding, Competitiveen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshHumansen_US
dc.subject.meshHybridomasen_US
dc.subject.meshImmune Sera - Immunologyen_US
dc.subject.meshImmunoassayen_US
dc.subject.meshInsect Vectors - Parasitologyen_US
dc.subject.meshMalaria - Immunology - Transmissionen_US
dc.subject.meshPlasmodium Vivax - Immunologyen_US
dc.titleMonoclonal and polyclonal antibodies both block and enhance transmission of human Plasmodium vivax malariaen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3041855-
dc.identifier.scopuseid_2-s2.0-0023790113en_US
dc.identifier.volume39en_US
dc.identifier.issue1en_US
dc.identifier.spage26en_US
dc.identifier.epage32en_US
dc.identifier.isiWOS:A1988P675500005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridPremawansa, S=6601964639en_US
dc.identifier.scopusauthoridRanawaka, MBR=7801554097en_US
dc.identifier.scopusauthoridUdagama, PV=6505767945en_US
dc.identifier.scopusauthoridMunasinghe, YD=6504111896en_US
dc.identifier.scopusauthoridNanayakkara, MV=6506356377en_US
dc.identifier.scopusauthoridGamage, CP=6602278025en_US
dc.identifier.scopusauthoridCarter, R=7402936927en_US
dc.identifier.scopusauthoridDavid, PH=7201509648en_US
dc.identifier.scopusauthoridMendis, KN=7004958149en_US

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