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Article: Demonstration of antigenic polymorphism in Plasmodium vivax malaria with a panel of 30 monoclonal antibodies

TitleDemonstration of antigenic polymorphism in Plasmodium vivax malaria with a panel of 30 monoclonal antibodies
Authors
Issue Date1987
Citation
Infection And Immunity, 1987, v. 55 n. 11, p. 2604-2611 How to Cite?
AbstractA panel of 30 monoclonal antibodies was established against asexual erythrocytic stages of Plasmodium vivax and used to investigate the antigenic composition of the parasite. At least 38 different antigenic polypeptides of P. vivax were characterized by the Western blot technique. The possible location of these antigens, as well as their stage and species specificity, was determined on the basis of the staining patterns produced by these antibodies on air-dried parasites in the indirect immunofluorescence test. Immunofluorescence performed with 30 different monoclonal antibodies on 50 different isolates of P. vivax obtained from patients showed that a high level of antigenic polymorphism prevailed in P. vivax. Only six monoclonal antibodies reacted with epitopes that were represented in more than 80% of parasite isolates, and therefore, appeared to be relatively conserved among different isolates. The other 24 monoclonal antibodies reacted with only 20 to 70% of parasite isolates.
Persistent Identifierhttp://hdl.handle.net/10722/179733
ISSN
2015 Impact Factor: 3.603
2015 SCImago Journal Rankings: 2.342
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorUdagama, PVen_US
dc.contributor.authorDavid, PHen_US
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorAriyaratne, YGen_US
dc.contributor.authorPerera, KLRLen_US
dc.contributor.authorMendis, KNen_US
dc.date.accessioned2012-12-19T10:04:08Z-
dc.date.available2012-12-19T10:04:08Z-
dc.date.issued1987en_US
dc.identifier.citationInfection And Immunity, 1987, v. 55 n. 11, p. 2604-2611en_US
dc.identifier.issn0019-9567en_US
dc.identifier.urihttp://hdl.handle.net/10722/179733-
dc.description.abstractA panel of 30 monoclonal antibodies was established against asexual erythrocytic stages of Plasmodium vivax and used to investigate the antigenic composition of the parasite. At least 38 different antigenic polypeptides of P. vivax were characterized by the Western blot technique. The possible location of these antigens, as well as their stage and species specificity, was determined on the basis of the staining patterns produced by these antibodies on air-dried parasites in the indirect immunofluorescence test. Immunofluorescence performed with 30 different monoclonal antibodies on 50 different isolates of P. vivax obtained from patients showed that a high level of antigenic polymorphism prevailed in P. vivax. Only six monoclonal antibodies reacted with epitopes that were represented in more than 80% of parasite isolates, and therefore, appeared to be relatively conserved among different isolates. The other 24 monoclonal antibodies reacted with only 20 to 70% of parasite isolates.en_US
dc.languageengen_US
dc.relation.ispartofInfection and Immunityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntibodies, Protozoan - Immunologyen_US
dc.subject.meshAntibody Specificityen_US
dc.subject.meshAntigens, Protozoan - Immunologyen_US
dc.subject.meshErythrocytes - Parasitologyen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshMalaria - Parasitologyen_US
dc.subject.meshPlasmodium Vivax - Immunologyen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshProteins - Immunologyen_US
dc.titleDemonstration of antigenic polymorphism in Plasmodium vivax malaria with a panel of 30 monoclonal antibodiesen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3312003-
dc.identifier.scopuseid_2-s2.0-0023270201en_US
dc.identifier.volume55en_US
dc.identifier.issue11en_US
dc.identifier.spage2604en_US
dc.identifier.epage2611en_US
dc.identifier.isiWOS:A1987K520400011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridUdagama, PV=6505767945en_US
dc.identifier.scopusauthoridDavid, PH=7201509648en_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridAriyaratne, YG=11238780000en_US
dc.identifier.scopusauthoridPerera, KLRL=7005580276en_US
dc.identifier.scopusauthoridMendis, KN=7004958149en_US

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