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Article: Monoclonal antibodies against the flavivirus West Nile

TitleMonoclonal antibodies against the flavivirus West Nile
Authors
Issue Date1982
PublisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.org
Citation
Journal Of General Virology, 1982, v. 58 n. 2, p. 283-289 How to Cite?
AbstractMonoclonal antibodies having three different specificities have been prepared against the Egypt 101 strain of West Nile virus (WNV). All were reactive against the envelope glycoprotein in radioimmune precipitation tests, and all enhanced WNV replication in the mouse macrophage line P388D1. One antibody, which is of IgG2a subclass, had strong neutralizing activity against the homologous virus, although it failed to neutralize a different WNV strain. The other two antibodies, both of IgG1 subclass, had little neutralizing activity, but one had strong reactivity with the haemagglutinin of the inducing virus and other flavivirus haemagglutinins.
Persistent Identifierhttp://hdl.handle.net/10722/179730
ISSN
2015 Impact Factor: 3.192
2015 SCImago Journal Rankings: 1.741

 

DC FieldValueLanguage
dc.contributor.authorPeiris, JSMen_US
dc.contributor.authorPorterfield, JSen_US
dc.contributor.authorRoehrig, JTen_US
dc.date.accessioned2012-12-19T10:04:07Z-
dc.date.available2012-12-19T10:04:07Z-
dc.date.issued1982en_US
dc.identifier.citationJournal Of General Virology, 1982, v. 58 n. 2, p. 283-289en_US
dc.identifier.issn0022-1317en_US
dc.identifier.urihttp://hdl.handle.net/10722/179730-
dc.description.abstractMonoclonal antibodies having three different specificities have been prepared against the Egypt 101 strain of West Nile virus (WNV). All were reactive against the envelope glycoprotein in radioimmune precipitation tests, and all enhanced WNV replication in the mouse macrophage line P388D1. One antibody, which is of IgG2a subclass, had strong neutralizing activity against the homologous virus, although it failed to neutralize a different WNV strain. The other two antibodies, both of IgG1 subclass, had little neutralizing activity, but one had strong reactivity with the haemagglutinin of the inducing virus and other flavivirus haemagglutinins.en_US
dc.languageengen_US
dc.publisherSociety for General Microbiology. The Journal's web site is located at http://vir.sgmjournals.orgen_US
dc.relation.ispartofJournal of General Virologyen_US
dc.subject.meshAntibodies, Monoclonal - Immunologyen_US
dc.subject.meshAntibodies, Viral - Immunologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshHemagglutination Inhibition Testsen_US
dc.subject.meshMacrophagesen_US
dc.subject.meshNeutralization Testsen_US
dc.subject.meshPrecipitin Testsen_US
dc.subject.meshViral Envelope Proteinsen_US
dc.subject.meshViral Plaque Assayen_US
dc.subject.meshViral Proteins - Immunologyen_US
dc.subject.meshWest Nile Virus - Growth & Development - Immunologyen_US
dc.titleMonoclonal antibodies against the flavivirus West Nileen_US
dc.typeArticleen_US
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hken_US
dc.identifier.authorityPeiris, JSM=rp00410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7061990-
dc.identifier.scopuseid_2-s2.0-0020083436en_US
dc.identifier.volume58en_US
dc.identifier.issue2en_US
dc.identifier.spage283en_US
dc.identifier.epage289en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridPeiris, JSM=7005486823en_US
dc.identifier.scopusauthoridPorterfield, JS=7005608715en_US
dc.identifier.scopusauthoridRoehrig, JT=7005611442en_US

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