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Conference Paper: Insights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians

TitleInsights into the evolution of proglucagon-derived peptides and receptors in fish and amphibians
Authors
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2010, v. 1200, p. 15-32 How to Cite?
AbstractGlucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon genes or exons that are likely resultant of duplication events. Through phylogenetic analysis and examination of their respective functions, the proglucagon ligand-receptor pairs are believed to have evolved independently before acquiring specificity for one another. This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species. © 2010 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/179605
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, SYLen_US
dc.contributor.authorLee, LTOen_US
dc.contributor.authorChow, BKCen_US
dc.date.accessioned2012-12-19T10:00:09Z-
dc.date.available2012-12-19T10:00:09Z-
dc.date.issued2010en_US
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2010, v. 1200, p. 15-32en_US
dc.identifier.issn0077-8923en_US
dc.identifier.urihttp://hdl.handle.net/10722/179605-
dc.description.abstractGlucagon and the glucagon-like peptides (GLP-1 and GLP-2) share a common evolutionary origin and are triplication products of an ancestral glucagon exon. In mammals, a standard scenario is found where only a single proglucagon-derived peptide set exists. However, fish and amphibians have either multiple proglucagon genes or exons that are likely resultant of duplication events. Through phylogenetic analysis and examination of their respective functions, the proglucagon ligand-receptor pairs are believed to have evolved independently before acquiring specificity for one another. This review will provide a comprehensive overview of current knowledge of proglucagon-derived peptides and receptors, with particular focus on fish and amphibian species. © 2010 New York Academy of Sciences.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.subject.meshAmphibians - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Evolutionen_US
dc.subject.meshFishes - Geneticsen_US
dc.subject.meshPeptides - Geneticsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshProglucagon - Geneticsen_US
dc.subject.meshReceptors, Cell Surface - Geneticsen_US
dc.titleInsights into the evolution of proglucagon-derived peptides and receptors in fish and amphibiansen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_US
dc.identifier.emailChow, BKC: bkcc@hku.hken_US
dc.identifier.authorityLee, LTO=rp00727en_US
dc.identifier.authorityChow, BKC=rp00681en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1749-6632.2010.05505.xen_US
dc.identifier.pmid20633130-
dc.identifier.scopuseid_2-s2.0-77954611764en_US
dc.identifier.hkuros182602-
dc.identifier.hkuros175448-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954611764&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1200en_US
dc.identifier.spage15en_US
dc.identifier.epage32en_US
dc.identifier.isiWOS:000282839600002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNg, SYL=36499721800en_US
dc.identifier.scopusauthoridLee, LTO=8367269000en_US
dc.identifier.scopusauthoridChow, BKC=7102826193en_US
dc.identifier.citeulike7470088-

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