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Conference Paper: Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells

TitleLocalization of small heterodimer partner (SHP) and secretin in mouse duodenal cells
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1
Citation
Annals Of The New York Academy Of Sciences, 2006, v. 1070, p. 371-375 How to Cite?
AbstractPrevious studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promoter by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene. © 2006 New York Academy of Sciences.
Persistent Identifierhttp://hdl.handle.net/10722/179590
ISSN
2015 Impact Factor: 4.518
2015 SCImago Journal Rankings: 2.389
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, IPYen_US
dc.contributor.authorLee, LTOen_US
dc.contributor.authorChoi, HSen_US
dc.contributor.authorChow, BKCen_US
dc.date.accessioned2012-12-19T10:00:03Z-
dc.date.available2012-12-19T10:00:03Z-
dc.date.issued2006en_US
dc.identifier.citationAnnals Of The New York Academy Of Sciences, 2006, v. 1070, p. 371-375en_US
dc.identifier.issn0077-8923en_US
dc.identifier.urihttp://hdl.handle.net/10722/179590-
dc.description.abstractPrevious studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promoter by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene. © 2006 New York Academy of Sciences.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journal.asp?ref=0077-8923&site=1en_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasic Helix-Loop-Helix Transcription Factors - Genetics - Metabolismen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshDuodenum - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshNerve Tissue Proteins - Genetics - Metabolismen_US
dc.subject.meshPromoter Regions, Genetic - Geneticsen_US
dc.subject.meshReceptors, Cytoplasmic And Nuclear - Metabolismen_US
dc.subject.meshSecretin - Genetics - Metabolismen_US
dc.titleLocalization of small heterodimer partner (SHP) and secretin in mouse duodenal cellsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_US
dc.identifier.emailChow, BKC: bkcc@hku.hken_US
dc.identifier.authorityLee, LTO=rp00727en_US
dc.identifier.authorityChow, BKC=rp00681en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1196/annals.1317.047en_US
dc.identifier.pmid16888194-
dc.identifier.scopuseid_2-s2.0-33746459319en_US
dc.identifier.hkuros122734-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746459319&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1070en_US
dc.identifier.spage371en_US
dc.identifier.epage375en_US
dc.identifier.isiWOS:000240364200051-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLam, IPY=14050702700en_US
dc.identifier.scopusauthoridLee, LTO=8367269000en_US
dc.identifier.scopusauthoridChoi, HS=7404338771en_US
dc.identifier.scopusauthoridChow, BKC=7102826193en_US

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