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Conference Paper: Association of Estrogen Receptor α and Vitamin D Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Males

TitleAssociation of Estrogen Receptor α and Vitamin D Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Males
Authors
Issue Date2004
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223
Citation
Calcified Tissue International, 2004, v. 74 n. 3, p. 270-276 How to Cite?
AbstractOsteoporosis is a common health problem not only in females but also in males, however, studies of osteoporosis in males are relatively rare compared to those in females. This is especially true in genetics studies. We evaluated the effects of PvuII and XbaI polymorphisms in the estrogen receptor α (ER-α) gene and ApaI polymorphism in the vitamin D receptor (VDR) gene on BMD variation in a random sample of 352 unrelated males from 401 Chinese nuclear families. BMD was measured at the lumbar spine (L1-L4) and hip (femoral neck, trochanter, intertrochanteric region). Raw BMD values were adjusted by age, age 2, height, and weight as covariates. We found no significant results for the 3 individual markers on BMD variation, however, ER-α haplotype analyses yielded some interesting results. Carriers of haplotype pX had a 4.98% lower BMD at the trochanter (P = 0.02) and 3.55% lower BMD at the lumbar spine (P = 0.09) than non-carriers. PX subjects had a 3.42% higher BMD at the trochanter and 3.26% higher BMD at the lumbar spine than others (P = 0.07 and P = 0.10, respectively). Such results were highly comparable with the significant or nearly significant interactions between ER-PvuII and ER-XbaI on BMD values at the trochanter (P = 0.03) and spine (P = 0.11). No significant results were observed for the interactions between ER-PvuII and VDR-ApaI, between ER-XbaI and VDR-ApaI, and between any of ER-α haplotypes and VDR-ApaI locus. Our results suggest that the ER-α haplotypes, not individual markers, may be associated with BMD variation at some skeletal sites in our Chinese male samples.
Persistent Identifierhttp://hdl.handle.net/10722/179586
ISSN
2015 Impact Factor: 3.052
2015 SCImago Journal Rankings: 1.166
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLong, JRen_US
dc.contributor.authorZhang, YYen_US
dc.contributor.authorLiu, PYen_US
dc.contributor.authorLiu, YJen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorZhao, LJen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T10:00:02Z-
dc.date.available2012-12-19T10:00:02Z-
dc.date.issued2004en_US
dc.identifier.citationCalcified Tissue International, 2004, v. 74 n. 3, p. 270-276en_US
dc.identifier.issn0171-967Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179586-
dc.description.abstractOsteoporosis is a common health problem not only in females but also in males, however, studies of osteoporosis in males are relatively rare compared to those in females. This is especially true in genetics studies. We evaluated the effects of PvuII and XbaI polymorphisms in the estrogen receptor α (ER-α) gene and ApaI polymorphism in the vitamin D receptor (VDR) gene on BMD variation in a random sample of 352 unrelated males from 401 Chinese nuclear families. BMD was measured at the lumbar spine (L1-L4) and hip (femoral neck, trochanter, intertrochanteric region). Raw BMD values were adjusted by age, age 2, height, and weight as covariates. We found no significant results for the 3 individual markers on BMD variation, however, ER-α haplotype analyses yielded some interesting results. Carriers of haplotype pX had a 4.98% lower BMD at the trochanter (P = 0.02) and 3.55% lower BMD at the lumbar spine (P = 0.09) than non-carriers. PX subjects had a 3.42% higher BMD at the trochanter and 3.26% higher BMD at the lumbar spine than others (P = 0.07 and P = 0.10, respectively). Such results were highly comparable with the significant or nearly significant interactions between ER-PvuII and ER-XbaI on BMD values at the trochanter (P = 0.03) and spine (P = 0.11). No significant results were observed for the interactions between ER-PvuII and VDR-ApaI, between ER-XbaI and VDR-ApaI, and between any of ER-α haplotypes and VDR-ApaI locus. Our results suggest that the ER-α haplotypes, not individual markers, may be associated with BMD variation at some skeletal sites in our Chinese male samples.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00223en_US
dc.relation.ispartofCalcified Tissue Internationalen_US
dc.subject.meshAbsorptiometry, Photonen_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshBone And Bones - Metabolism - Radiographyen_US
dc.subject.meshChinaen_US
dc.subject.meshEstrogen Receptor Alphaen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis - Geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.subject.meshReceptors, Estrogen - Geneticsen_US
dc.titleAssociation of Estrogen Receptor α and Vitamin D Receptor Gene Polymorphisms with Bone Mineral Density in Chinese Malesen_US
dc.typeConference_Paperen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00223-003-0087-4en_US
dc.identifier.pmid14595531-
dc.identifier.scopuseid_2-s2.0-1542614999en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542614999&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue3en_US
dc.identifier.spage270en_US
dc.identifier.epage276en_US
dc.identifier.isiWOS:000220252700007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridZhang, YY=12781205700en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridLiu, YJ=36065513000en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridZhao, LJ=7404455505en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

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