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Article: Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF

TitleEvaluation of MRI models in the measurement of CMRO2 and its relationship with CBF
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2008, v. 60 n. 2, p. 380-389 How to Cite?
AbstractThe aim of this study was to investigate the various MRI biophysical models in the measurements of local cerebral metabolic rate of oxygen (CMRO 2) and the corresponding relationship with cerebral blood flow (CBF) during brain activation. This aim was addressed by simultaneously measuring the relative changes in CBF, cerebral blood volume (CBV), and blood oxygen level dependent (BOLD) MRI signals in the human visual cortex during visual stimulation. A radial checkerboard delivered flash stimulation at five different frequencies. Two MRI models, the single-compartment model (SCM) and the multicompartment model (MCM), were used to determine the relative changes in CMRO2 using three methods: [1] SCM with parameters identical to those used in a prior MRI study (M = 0.22; α = 0.38); [2] SCM with directly measured parameters (M from hypercapnia and α from measured δCBV and δCBF); and [3] MCM. The magnitude of relative changes in CMRO2 and the nonlinear relationship between CBF and CMRO2 obtained with Methods [2] and [3] were not in agreement with those obtained using Method [1]. However, the results of Methods [2] and [3] were aligned with positron emission tomography findings from the literature. Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO2 and determining the flow-metabolism relationship. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/179524
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, ALen_US
dc.contributor.authorFox, PTen_US
dc.contributor.authorYang, Yen_US
dc.contributor.authorLu, Hen_US
dc.contributor.authorTan, LHen_US
dc.contributor.authorGao, JHen_US
dc.date.accessioned2012-12-19T09:58:12Z-
dc.date.available2012-12-19T09:58:12Z-
dc.date.issued2008en_US
dc.identifier.citationMagnetic Resonance In Medicine, 2008, v. 60 n. 2, p. 380-389en_US
dc.identifier.issn0740-3194en_US
dc.identifier.urihttp://hdl.handle.net/10722/179524-
dc.description.abstractThe aim of this study was to investigate the various MRI biophysical models in the measurements of local cerebral metabolic rate of oxygen (CMRO 2) and the corresponding relationship with cerebral blood flow (CBF) during brain activation. This aim was addressed by simultaneously measuring the relative changes in CBF, cerebral blood volume (CBV), and blood oxygen level dependent (BOLD) MRI signals in the human visual cortex during visual stimulation. A radial checkerboard delivered flash stimulation at five different frequencies. Two MRI models, the single-compartment model (SCM) and the multicompartment model (MCM), were used to determine the relative changes in CMRO2 using three methods: [1] SCM with parameters identical to those used in a prior MRI study (M = 0.22; α = 0.38); [2] SCM with directly measured parameters (M from hypercapnia and α from measured δCBV and δCBF); and [3] MCM. The magnitude of relative changes in CMRO2 and the nonlinear relationship between CBF and CMRO2 obtained with Methods [2] and [3] were not in agreement with those obtained using Method [1]. However, the results of Methods [2] and [3] were aligned with positron emission tomography findings from the literature. Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO2 and determining the flow-metabolism relationship. © 2008 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_US
dc.relation.ispartofMagnetic Resonance in Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshCerebrovascular Circulation - Physiologyen_US
dc.subject.meshComputer Simulationen_US
dc.subject.meshEvoked Potentials, Visual - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Interpretation, Computer-Assisted - Methodsen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Neurologicalen_US
dc.subject.meshOxygen Consumption - Physiologyen_US
dc.subject.meshVisual Cortex - Physiologyen_US
dc.titleEvaluation of MRI models in the measurement of CMRO2 and its relationship with CBFen_US
dc.typeArticleen_US
dc.identifier.emailTan, LH: tanlh@hku.hken_US
dc.identifier.authorityTan, LH=rp01202en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/mrm.21655en_US
dc.identifier.pmid18666102-
dc.identifier.scopuseid_2-s2.0-49049116105en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-49049116105&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue2en_US
dc.identifier.spage380en_US
dc.identifier.epage389en_US
dc.identifier.isiWOS:000258105800018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLin, AL=16835064700en_US
dc.identifier.scopusauthoridFox, PT=7402680249en_US
dc.identifier.scopusauthoridYang, Y=7409387192en_US
dc.identifier.scopusauthoridLu, H=8386439700en_US
dc.identifier.scopusauthoridTan, LH=7402233462en_US
dc.identifier.scopusauthoridGao, JH=7404475674en_US
dc.identifier.citeulike3738976-

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