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Article: Protective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells

TitleProtective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cells
Authors
Issue Date2011
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2011, v. 25 n. 3, p. 435-443 How to Cite?
AbstractAggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) againstAβ 25-35 and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5 μM Aβ 25-35 caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro-apoptotic protein Bax and caspase-3 activation. All these effects induced byAβ 25-35 were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine-induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against Aβ toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase-3. Further structure-activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright © 2010 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179457
ISSN
2015 Impact Factor: 2.694
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSong, JXen_US
dc.contributor.authorLin, Xen_US
dc.contributor.authorWong, RNSen_US
dc.contributor.authorSze, SCWen_US
dc.contributor.authorTong, Yen_US
dc.contributor.authorShaw, PCen_US
dc.contributor.authorZhang, YBen_US
dc.date.accessioned2012-12-19T09:56:45Z-
dc.date.available2012-12-19T09:56:45Z-
dc.date.issued2011en_US
dc.identifier.citationPhytotherapy Research, 2011, v. 25 n. 3, p. 435-443en_US
dc.identifier.issn0951-418Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179457-
dc.description.abstractAggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and schisandrin C) isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) againstAβ 25-35 and homocysteine toxicity in PC12 cells was studied. Exposure of PC12 cells to 0.5 μM Aβ 25-35 caused significant cell death, increased the number of apoptotic cells, elevated reactive oxygen species, increased the levels of the pro-apoptotic protein Bax and caspase-3 activation. All these effects induced byAβ 25-35 were markedly reversed by schisandrin B and schisandrin C pretreatment, while schisandrin and schisantherin A had no obvious effects. Meanwhile, schisandrin B and schisandrin C reversed homocysteine-induced cytotoxicity. The results indicated that schisandrin B and schisandrin C protected PC12 cells against Aβ toxicity by attenuating ROS production and modulating the apoptotic signal pathway through Bax and caspase-3. Further structure-activity analysis of Schisandra lignans and evaluations of their neuroprotective effects using AD animal models are warranted. Copyright © 2010 John Wiley & Sons, Ltd.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567en_US
dc.relation.ispartofPhytotherapy Researchen_US
dc.subject.meshAmyloid Beta-Peptides - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshCaspase 3 - Metabolismen_US
dc.subject.meshCyclooctanes - Pharmacologyen_US
dc.subject.meshDioxolesen_US
dc.subject.meshHomocysteine - Toxicityen_US
dc.subject.meshLignans - Pharmacologyen_US
dc.subject.meshNeuroprotective Agents - Pharmacologyen_US
dc.subject.meshPc12 Cellsen_US
dc.subject.meshPeptide Fragments - Toxicityen_US
dc.subject.meshPolycyclic Compoundsen_US
dc.subject.meshRatsen_US
dc.subject.meshReactive Oxygen Species - Metabolismen_US
dc.subject.meshSchisandra - Chemistryen_US
dc.subject.meshBcl-2-Associated X Protein - Metabolismen_US
dc.titleProtective effects of dibenzocyclooctadiene lignans from Schisandra chinensis against beta-amyloid and homocysteine neurotoxicity in PC12 cellsen_US
dc.typeArticleen_US
dc.identifier.emailSze, SCW: stephens@hku.hken_US
dc.identifier.emailTong, Y: tongyao@hku.hken_US
dc.identifier.emailZhang, YB: ybzhang@hku.hken_US
dc.identifier.authoritySze, SCW=rp00514en_US
dc.identifier.authorityTong, Y=rp00509en_US
dc.identifier.authorityZhang, YB=rp01410en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ptr.3269en_US
dc.identifier.pmid20740476-
dc.identifier.scopuseid_2-s2.0-79952232564en_US
dc.identifier.hkuros172907-
dc.identifier.hkuros197192-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79952232564&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.spage435en_US
dc.identifier.epage443en_US
dc.identifier.isiWOS:000288133000019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridSong, JX=24339343800en_US
dc.identifier.scopusauthoridLin, X=36101204400en_US
dc.identifier.scopusauthoridWong, RNS=7402126957en_US
dc.identifier.scopusauthoridSze, SCW=23482617000en_US
dc.identifier.scopusauthoridTong, Y=9045384000en_US
dc.identifier.scopusauthoridShaw, PC=35599523600en_US
dc.identifier.scopusauthoridZhang, YB=23483121900en_US

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