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Article: The disposition and pharmacokinetics of Dioscorea nipponica Makino extract in rats

TitleThe disposition and pharmacokinetics of Dioscorea nipponica Makino extract in rats
Authors
Keywords3H Labeled
Disposition
Pharmacokinetics
Total Saponins Of Dioscorea
Issue Date2008
PublisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/AJB/index.htm
Citation
African Journal Of Biotechnology, 2008, v. 7 n. 22, p. 4015-4018 How to Cite?
AbstractThis study was aimed to investigate the disposition and pharmacokinetics of the total saponins of dioscorea (TSD) in rats. Male Sprague-Dawley rats were orally administrated with 3H labeled TSD at a single dose ratio of 80 mg TSD per 1 kg rat. Blood samples and feces were collected at different time points to measure the level of TSD activity. At the final time point, determination of the disposition of TSD in lung, kidney, heart, liver, adrenal, and small intestine were performed. From the blood samples' emission of radioactivity, pharmacokinetic parameters were derived as T1/2 = 33.33 ± 4.48 h, T max = 6.5 ± 0.71 h, AUC = 119400 ± 421097.67, and C max = 2643.33 ± 192.26 dpm/ml. There was 51.609% of 3H labeled substance excreted in 24 h. These results suggested that blood concentration of 3H-TSD was extremely low and the majority of TSD was excreted in the feces. The TSD was extensively distributed to multitissues. The radioactivity level was measured to be the highest in the liver, adrenal gland, and wall of the gastrointestinal tract. The radioactivity of TSD was still being detected in blood after 96 h. This showed TSD was excreted in vivo very slowly. © 2008 Academic Journals.
Persistent Identifierhttp://hdl.handle.net/10722/179449
ISSN
2010 Impact Factor: 0.573
2015 SCImago Journal Rankings: 0.295
References

 

DC FieldValueLanguage
dc.contributor.authorRen, Hen_US
dc.contributor.authorChen, JPen_US
dc.contributor.authorTan, BYen_US
dc.contributor.authorWang, DMen_US
dc.contributor.authorLin, SHen_US
dc.contributor.authorZhang, YPen_US
dc.contributor.authorYang, DPen_US
dc.contributor.authorLoo, TYWen_US
dc.contributor.authorYeung, HSBen_US
dc.contributor.authorJin, Men_US
dc.contributor.authorLi, Xen_US
dc.date.accessioned2012-12-19T09:56:40Z-
dc.date.available2012-12-19T09:56:40Z-
dc.date.issued2008en_US
dc.identifier.citationAfrican Journal Of Biotechnology, 2008, v. 7 n. 22, p. 4015-4018en_US
dc.identifier.issn1684-5315en_US
dc.identifier.urihttp://hdl.handle.net/10722/179449-
dc.description.abstractThis study was aimed to investigate the disposition and pharmacokinetics of the total saponins of dioscorea (TSD) in rats. Male Sprague-Dawley rats were orally administrated with 3H labeled TSD at a single dose ratio of 80 mg TSD per 1 kg rat. Blood samples and feces were collected at different time points to measure the level of TSD activity. At the final time point, determination of the disposition of TSD in lung, kidney, heart, liver, adrenal, and small intestine were performed. From the blood samples' emission of radioactivity, pharmacokinetic parameters were derived as T1/2 = 33.33 ± 4.48 h, T max = 6.5 ± 0.71 h, AUC = 119400 ± 421097.67, and C max = 2643.33 ± 192.26 dpm/ml. There was 51.609% of 3H labeled substance excreted in 24 h. These results suggested that blood concentration of 3H-TSD was extremely low and the majority of TSD was excreted in the feces. The TSD was extensively distributed to multitissues. The radioactivity level was measured to be the highest in the liver, adrenal gland, and wall of the gastrointestinal tract. The radioactivity of TSD was still being detected in blood after 96 h. This showed TSD was excreted in vivo very slowly. © 2008 Academic Journals.en_US
dc.languageengen_US
dc.publisherAcademic Journals. The Journal's web site is located at http://www.academicjournals.org/AJB/index.htmen_US
dc.relation.ispartofAfrican Journal of Biotechnologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject3H Labeleden_US
dc.subjectDispositionen_US
dc.subjectPharmacokineticsen_US
dc.subjectTotal Saponins Of Dioscoreaen_US
dc.titleThe disposition and pharmacokinetics of Dioscorea nipponica Makino extract in ratsen_US
dc.typeArticleen_US
dc.identifier.emailChen, JP: abchen@hku.hken_US
dc.identifier.authorityChen, JP=rp01316en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.scopuseid_2-s2.0-57149120541en_US
dc.identifier.hkuros155518-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-57149120541&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume7en_US
dc.identifier.issue22en_US
dc.identifier.spage4015en_US
dc.identifier.epage4018en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRen, H=25724687500en_US
dc.identifier.scopusauthoridJian, PC=22733695400en_US
dc.identifier.scopusauthoridBin, YT=25724060400en_US
dc.identifier.scopusauthoridDong, MW=55136709600en_US
dc.identifier.scopusauthoridShu, HL=25724652600en_US
dc.identifier.scopusauthoridZhang, YP=35314466700en_US
dc.identifier.scopusauthoridYang, DP=55242475900en_US
dc.identifier.scopusauthoridLoo, TYW=7006008583en_US
dc.identifier.scopusauthoridYeung, HSB=25724816200en_US
dc.identifier.scopusauthoridJin, M=7202559492en_US
dc.identifier.scopusauthoridLi, X=37109263100en_US

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