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Article: Coadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures

TitleCoadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizures
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 2003, v. 74 n. 3, p. 565-571 How to Cite?
AbstractThe development of tolerance to therapeutic effects of antiepileptic drugs can be a problem in the treatment of epilepsy, bipolar disorder, and pain syndromes. In the present study, acute treatment with the new antiepileptic drug lamotrigine (LTG, 15 mg/kg) markedly suppressed seizure stage and seizure duration in amygdala-kindled rats; but this antiseizure effect was rapidly lost following 4-8 days of repeated treatment. When gabapentin (GBP, 20 mg/kg) was coadministered with LTG, the ability of LTG to suppress seizure stage, seizure duration, and after-discharge (AD) duration was markedly extended. In addition, GBP coadministration with LTG decreased the number of animals that developed LTG-related running fits (Stage 6 seizures) and lengthened the number of days required to develop running fits or complete tolerance. Neither acute nor repeated treatment with MK-801 (0.3 mg/kg), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, had effects on kindled seizures. However, cotreatment with MK-801 markedly extended the anticonvulsant effects of LTG on the three seizure indices and reduced running fits. These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored. © 2002 Elsevier Science Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179415
ISSN
2015 Impact Factor: 2.537
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, ZJen_US
dc.contributor.authorRussell, Sen_US
dc.contributor.authorObeng, Ken_US
dc.contributor.authorPostma, Ten_US
dc.contributor.authorObrocea, Gen_US
dc.contributor.authorWeiss, SRBen_US
dc.contributor.authorPost, RMen_US
dc.date.accessioned2012-12-19T09:56:17Z-
dc.date.available2012-12-19T09:56:17Z-
dc.date.issued2003en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 2003, v. 74 n. 3, p. 565-571en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/179415-
dc.description.abstractThe development of tolerance to therapeutic effects of antiepileptic drugs can be a problem in the treatment of epilepsy, bipolar disorder, and pain syndromes. In the present study, acute treatment with the new antiepileptic drug lamotrigine (LTG, 15 mg/kg) markedly suppressed seizure stage and seizure duration in amygdala-kindled rats; but this antiseizure effect was rapidly lost following 4-8 days of repeated treatment. When gabapentin (GBP, 20 mg/kg) was coadministered with LTG, the ability of LTG to suppress seizure stage, seizure duration, and after-discharge (AD) duration was markedly extended. In addition, GBP coadministration with LTG decreased the number of animals that developed LTG-related running fits (Stage 6 seizures) and lengthened the number of days required to develop running fits or complete tolerance. Neither acute nor repeated treatment with MK-801 (0.3 mg/kg), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, had effects on kindled seizures. However, cotreatment with MK-801 markedly extended the anticonvulsant effects of LTG on the three seizure indices and reduced running fits. These data indicate that cotreatment with either GBP or MK-801 slows tolerance development to the anticonvulsant effects of LTG on kindled seizures. Therapeutic implications of the present study remain to be explored. © 2002 Elsevier Science Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subject.meshAcetic Acids - Administration & Dosageen_US
dc.subject.meshAminesen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnticonvulsants - Administration & Dosageen_US
dc.subject.meshCyclohexanecarboxylic Acidsen_US
dc.subject.meshDizocilpine Maleate - Administration & Dosageen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDrug Tolerance - Physiologyen_US
dc.subject.meshKindling, Neurologic - Drug Effects - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSeizures - Drug Therapy - Physiopathologyen_US
dc.subject.meshTriazines - Administration & Dosageen_US
dc.subject.meshGamma-Aminobutyric Aciden_US
dc.titleCoadministration of gabapentin or MK-801 with lamotrigine slows tolerance to its anticonvulsant effects on kindled seizuresen_US
dc.typeArticleen_US
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_US
dc.identifier.authorityZhang, ZJ=rp01297en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0091-3057(02)01035-3en_US
dc.identifier.pmid12543220-
dc.identifier.scopuseid_2-s2.0-0037306773en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037306773&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue3en_US
dc.identifier.spage565en_US
dc.identifier.epage571en_US
dc.identifier.isiWOS:000180769400007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_US
dc.identifier.scopusauthoridRussell, S=7401538133en_US
dc.identifier.scopusauthoridObeng, K=6701594477en_US
dc.identifier.scopusauthoridPostma, T=7003610812en_US
dc.identifier.scopusauthoridObrocea, G=6507780112en_US
dc.identifier.scopusauthoridWeiss, SRB=35448419700en_US
dc.identifier.scopusauthoridPost, RM=7202218145en_US

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