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Article: Investigation of the relationship between endometrial MMP activities and sex hormones in mature bitches

TitleInvestigation of the relationship between endometrial MMP activities and sex hormones in mature bitches
Authors
KeywordsDogs
Endometrium
Estrous Cycle
Matrix Metalloproteinase
Issue Date2011
Citation
Thai Journal Of Veterinary Medicine, 2011, v. 41 n. 3, p. 289-297 How to Cite?
AbstractEndometrial matrix metalloproteinases (MMPs) are extensively studied in humans. However, owing to the distinct differences of the estrous cycle of bitches, the expression and activities of endometrial MMPs regulated by sex hormones should be significantly different. To understand the effect of sex hormones on the activity of MMPs, this study investigates the activities of endometrial MMP-2 and MMP-9 during different phases of the estrous cycle in bitches through the use of gelatine zymography. Estradiol and progesterone concentrations were also determined using enzyme-linked fluorescent assay. The activities of the latent forms of both MMP-2 and -9 were significantly higher in metestrus (MP) and late diestrus phases (L-DP) than in anestrus (AP) and proestrus/estrus phases (EP) (p<0.05). Similarly, the activities of the active forms of both MMPs in L-DP were significantly higher than in the other phases of the estrous cycle (p<0.05). Significant correlations were found between progesterone and the activities of latent and active forms of MMP-9 during MP (r= -0.83, p<0.05 and r= 0.94, p<0.01, respectively). Considering our results, together with that of previous studies on the role of MMPs in the reproductive system, we hypothesize that endometrial MMP-2 and MMP-9 play a key role in successful fertilization.
Persistent Identifierhttp://hdl.handle.net/10722/179265
ISSN
2015 Impact Factor: 0.257
2015 SCImago Journal Rankings: 0.180
References

 

DC FieldValueLanguage
dc.contributor.authorShia, WYen_US
dc.contributor.authorChu, PCen_US
dc.contributor.authorChou, CCen_US
dc.contributor.authorLee, WMen_US
dc.date.accessioned2012-12-19T09:53:28Z-
dc.date.available2012-12-19T09:53:28Z-
dc.date.issued2011en_US
dc.identifier.citationThai Journal Of Veterinary Medicine, 2011, v. 41 n. 3, p. 289-297en_US
dc.identifier.issn0125-6491en_US
dc.identifier.urihttp://hdl.handle.net/10722/179265-
dc.description.abstractEndometrial matrix metalloproteinases (MMPs) are extensively studied in humans. However, owing to the distinct differences of the estrous cycle of bitches, the expression and activities of endometrial MMPs regulated by sex hormones should be significantly different. To understand the effect of sex hormones on the activity of MMPs, this study investigates the activities of endometrial MMP-2 and MMP-9 during different phases of the estrous cycle in bitches through the use of gelatine zymography. Estradiol and progesterone concentrations were also determined using enzyme-linked fluorescent assay. The activities of the latent forms of both MMP-2 and -9 were significantly higher in metestrus (MP) and late diestrus phases (L-DP) than in anestrus (AP) and proestrus/estrus phases (EP) (p<0.05). Similarly, the activities of the active forms of both MMPs in L-DP were significantly higher than in the other phases of the estrous cycle (p<0.05). Significant correlations were found between progesterone and the activities of latent and active forms of MMP-9 during MP (r= -0.83, p<0.05 and r= 0.94, p<0.01, respectively). Considering our results, together with that of previous studies on the role of MMPs in the reproductive system, we hypothesize that endometrial MMP-2 and MMP-9 play a key role in successful fertilization.en_US
dc.languageengen_US
dc.relation.ispartofThai Journal of Veterinary Medicineen_US
dc.subjectDogsen_US
dc.subjectEndometriumen_US
dc.subjectEstrous Cycleen_US
dc.subjectMatrix Metalloproteinaseen_US
dc.titleInvestigation of the relationship between endometrial MMP activities and sex hormones in mature bitchesen_US
dc.typeArticleen_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-83655165124en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83655165124&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue3en_US
dc.identifier.spage289en_US
dc.identifier.epage297en_US
dc.identifier.scopusauthoridShia, WY=37067874400en_US
dc.identifier.scopusauthoridChu, PC=55434249100en_US
dc.identifier.scopusauthoridChou, CC=55448525000en_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US

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