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Article: Oxidative damage in Parkinson disease: Measurement using accurate biomarkers

TitleOxidative damage in Parkinson disease: Measurement using accurate biomarkers
Authors
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
Citation
Free Radical Biology And Medicine, 2010, v. 48 n. 4, p. 560-566 How to Cite?
AbstractOxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F 2-isoprostanes (F 2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F 4-NPs), phospholipase A 2 (PLA 2) and platelet activating factor-acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F 2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F 4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA 2 and PAF-AH activities were lower, in PD patients compared to controls (p < 0.05). The levels of plasma F 2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (p trend < 0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (r = -0.305, p = 0.023) and plasma total HETEs (r = -0.285, p = 0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179176
ISSN
2015 Impact Factor: 5.784
2015 SCImago Journal Rankings: 2.468
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSeet, RCSen_US
dc.contributor.authorLee, CYJen_US
dc.contributor.authorLim, ECHen_US
dc.contributor.authorTan, JJHen_US
dc.contributor.authorQuek, AMLen_US
dc.contributor.authorChong, WLen_US
dc.contributor.authorLooi, WFen_US
dc.contributor.authorHuang, SHen_US
dc.contributor.authorWang, Hen_US
dc.contributor.authorChan, YHen_US
dc.contributor.authorHalliwell, Ben_US
dc.date.accessioned2012-12-19T09:52:35Z-
dc.date.available2012-12-19T09:52:35Z-
dc.date.issued2010en_US
dc.identifier.citationFree Radical Biology And Medicine, 2010, v. 48 n. 4, p. 560-566en_US
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/10722/179176-
dc.description.abstractOxidative damage has been implicated in the pathogenesis of Parkinson disease (PD) but the literature data are confusing. Using products of lipid and DNA oxidation measured by accurate methods, we assessed the extent of oxidative damage in PD patients. The levels of plasma F 2-isoprostanes (F 2-IsoPs), hydroxyeicosatetraenoic acid products (HETEs), cholesterol oxidation products, neuroprostanes (F 4-NPs), phospholipase A 2 (PLA 2) and platelet activating factor-acetylhydrolase (PAF-AH) activities, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), and serum high-sensitivity C-reactive protein were compared in 61 PD patients and 61 age-matched controls. The levels of plasma F 2-IsoPs, HETEs, 7β-and 27-hydroxycholesterol, 7-ketocholesterol, F 4-NPs, and urinary 8-OHdG were elevated, whereas the levels of plasma PLA 2 and PAF-AH activities were lower, in PD patients compared to controls (p < 0.05). The levels of plasma F 2-IsoPs, HETEs, and urinary 8-OHdG were higher in the early stages of PD (p trend < 0.05). There was a significant negative correlation between the cumulative intake of levodopa and urinary 8-OHdG (r = -0.305, p = 0.023) and plasma total HETEs (r = -0.285, p = 0.043). Oxidative damage markers are systemically elevated in PD, which may give clues about the relation of oxidative damage to the onset and progression of PD. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomeden_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.subject.meshAgeden_US
dc.subject.meshBiological Markers - Metabolismen_US
dc.subject.meshC-Reactive Protein - Chemistryen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCholesterol - Chemistryen_US
dc.subject.meshDna - Chemistryen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshF2-Isoprostanes - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydroxyeicosatetraenoic Acids - Chemistryen_US
dc.subject.meshLevodopa - Pharmacologyen_US
dc.subject.meshLipids - Chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshOxygen - Chemistryen_US
dc.subject.meshParkinson Disease - Blood - Diagnosis - Pathologyen_US
dc.titleOxidative damage in Parkinson disease: Measurement using accurate biomarkersen_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.freeradbiomed.2009.11.026en_US
dc.identifier.pmid19969070-
dc.identifier.scopuseid_2-s2.0-74149087316en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74149087316&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue4en_US
dc.identifier.spage560en_US
dc.identifier.epage566en_US
dc.identifier.isiWOS:000274235500011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSeet, RCS=10045357300en_US
dc.identifier.scopusauthoridLee, CYJ=13104265200en_US
dc.identifier.scopusauthoridLim, ECH=8945547100en_US
dc.identifier.scopusauthoridTan, JJH=8858541900en_US
dc.identifier.scopusauthoridQuek, AML=13605538000en_US
dc.identifier.scopusauthoridChong, WL=36522496900en_US
dc.identifier.scopusauthoridLooi, WF=36523459100en_US
dc.identifier.scopusauthoridHuang, SH=8367750600en_US
dc.identifier.scopusauthoridWang, H=13103566900en_US
dc.identifier.scopusauthoridChan, YH=7403675912en_US
dc.identifier.scopusauthoridHalliwell, B=7101878919en_US
dc.identifier.citeulike6358340-

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