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Article: Cross-talk between tight and anchoring junctions-lesson from the testis

TitleCross-talk between tight and anchoring junctions-lesson from the testis
Authors
Issue Date2008
Citation
Advances In Experimental Medicine And Biology, 2008, v. 636, p. 234-254 How to Cite?
AbstractSpermatogenesis takes place in the seminiferous tubules in adult testes such as rats, in which developing germ cells must traverse the seminiferous epithelium while spermatogonia (2n, diploid) undergo mitotic and meiotic divisions, and differentiate into elongated spermatids (1n, haploid). It is conceivable that this event involves extensive junction restructuring particularly at the blood-testis barrier (BTB, a structure that segregates the seminiferous epithelium into the basal and the adluminal compartments) that occurs at stages VII-VIII of the seminiferous epithelial cycle. As such, cross-talk between tight (TJ) and anchoring junctions [e.g., basal ectoplasmic specialization (basal ES), adherens junction (AJ), desmosome-like junction (DJ)] at the BTB must occur to coordinate the transient opening of the BTB to facilitate preleptotene spermatocyte migration. Interestingly, while there are extensively restructuring at the BTB during the epithelial cycle, the immunological barrier function of the BTB must be maintained without disruption even transiently. Recent studies using the androgen suppression and Adjudin models have shown that anchoring junction restructuring that leads to germ cell loss from the seminiferous epithelium also promotes the production of AJ (e.g., basal ES) proteins (such as N-cadherins, catenins) at the BTB site. We postulate the testis is using a similar mechanism during spermatogenesis at stage VIII of the epithelial cycle that these induced basal ES proteins, likely form a "patch" surrounding the BTB, transiently maintain the BTB integrity while TJ is "opened", such as induced by TGF-b3 or TNFa, to facilitate preleptotene spermatocyte migration. However, in other stages of the epithelial cycle other than VII and VIII when the BTB remains "closed" (for ∼10 days), anchoring junctions (e.g., AJ, DJ, and apical ES) restructuring continues to facilitate germ cell movement. Interestingly, the mechanism(s) that governs this communication between TJ and anchoring junction (e.g., basal ES and AJ) in the testis has remained obscure until recently. Herein, we provide a critical review based on the recently available data regarding the cross-talk between TJ and anchoring junction to allow simultaneous maintenance of the BTB and germ cell movement across the seminiferous epithelium. © 2008 Landes Bioscience and Springer Science+Business Media.
Persistent Identifierhttp://hdl.handle.net/10722/179174
ISSN
2015 Impact Factor: 1.953
2015 SCImago Journal Rankings: 0.887
References

 

DC FieldValueLanguage
dc.contributor.authorYan, HHNen_US
dc.contributor.authorMruk, DDen_US
dc.contributor.authorLee, WMen_US
dc.contributor.authorYan Cheng, Cen_US
dc.date.accessioned2012-12-19T09:52:33Z-
dc.date.available2012-12-19T09:52:33Z-
dc.date.issued2008en_US
dc.identifier.citationAdvances In Experimental Medicine And Biology, 2008, v. 636, p. 234-254en_US
dc.identifier.issn0065-2598en_US
dc.identifier.urihttp://hdl.handle.net/10722/179174-
dc.description.abstractSpermatogenesis takes place in the seminiferous tubules in adult testes such as rats, in which developing germ cells must traverse the seminiferous epithelium while spermatogonia (2n, diploid) undergo mitotic and meiotic divisions, and differentiate into elongated spermatids (1n, haploid). It is conceivable that this event involves extensive junction restructuring particularly at the blood-testis barrier (BTB, a structure that segregates the seminiferous epithelium into the basal and the adluminal compartments) that occurs at stages VII-VIII of the seminiferous epithelial cycle. As such, cross-talk between tight (TJ) and anchoring junctions [e.g., basal ectoplasmic specialization (basal ES), adherens junction (AJ), desmosome-like junction (DJ)] at the BTB must occur to coordinate the transient opening of the BTB to facilitate preleptotene spermatocyte migration. Interestingly, while there are extensively restructuring at the BTB during the epithelial cycle, the immunological barrier function of the BTB must be maintained without disruption even transiently. Recent studies using the androgen suppression and Adjudin models have shown that anchoring junction restructuring that leads to germ cell loss from the seminiferous epithelium also promotes the production of AJ (e.g., basal ES) proteins (such as N-cadherins, catenins) at the BTB site. We postulate the testis is using a similar mechanism during spermatogenesis at stage VIII of the epithelial cycle that these induced basal ES proteins, likely form a "patch" surrounding the BTB, transiently maintain the BTB integrity while TJ is "opened", such as induced by TGF-b3 or TNFa, to facilitate preleptotene spermatocyte migration. However, in other stages of the epithelial cycle other than VII and VIII when the BTB remains "closed" (for ∼10 days), anchoring junctions (e.g., AJ, DJ, and apical ES) restructuring continues to facilitate germ cell movement. Interestingly, the mechanism(s) that governs this communication between TJ and anchoring junction (e.g., basal ES and AJ) in the testis has remained obscure until recently. Herein, we provide a critical review based on the recently available data regarding the cross-talk between TJ and anchoring junction to allow simultaneous maintenance of the BTB and germ cell movement across the seminiferous epithelium. © 2008 Landes Bioscience and Springer Science+Business Media.en_US
dc.languageengen_US
dc.relation.ispartofAdvances in Experimental Medicine and Biologyen_US
dc.titleCross-talk between tight and anchoring junctions-lesson from the testisen_US
dc.typeArticleen_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/978-0-387-09597-4_13en_US
dc.identifier.pmid19856171-
dc.identifier.scopuseid_2-s2.0-73949155530en_US
dc.identifier.hkuros149052-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73949155530&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume636en_US
dc.identifier.spage234en_US
dc.identifier.epage254en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYan, HHN=14018807300en_US
dc.identifier.scopusauthoridMruk, DD=6701823934en_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US
dc.identifier.scopusauthoridYan Cheng, C=6602806090en_US

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