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Article: Chemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus

TitleChemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllus
Authors
Issue Date2009
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
Citation
Journal Of Agricultural And Food Chemistry, 2009, v. 57 n. 15, p. 6649-6655 How to Cite?
AbstractAn HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus. Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity. © 2009 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/179150
ISSN
2015 Impact Factor: 2.857
2015 SCImago Journal Rankings: 1.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, ZPen_US
dc.contributor.authorChen, Sen_US
dc.contributor.authorWang, Sen_US
dc.contributor.authorWang, XCen_US
dc.contributor.authorCheng, KWen_US
dc.contributor.authorWu, JJen_US
dc.contributor.authorYang, Den_US
dc.contributor.authorWang, Men_US
dc.date.accessioned2012-12-19T09:52:23Z-
dc.date.available2012-12-19T09:52:23Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2009, v. 57 n. 15, p. 6649-6655en_US
dc.identifier.issn0021-8561en_US
dc.identifier.urihttp://hdl.handle.net/10722/179150-
dc.description.abstractAn HPLC method was developed and validated to compare the chemical profiles and tyrosinase inhibitors in the woods, twigs, roots, and leaves of Artocarpus heterophyllus. Five active tyrosinase inhibitors including dihydromorin, steppogenin, norartocarpetin, artocarpanone, and artocarpesin were used as marker compounds in this HPLC method. It was discovered that the chemical profiles of A. heterophyllus twigs and woods are quite different. Systematic chromatographic methods were further applied to purify the chemicals in the twigs of A. heterophyllus. Four new phenolic compounds, including one isoprenylated 2-arylbenzofuran derivative, artoheterophyllin A (1), and three isoprenylated flavonoids, artoheterophyllin B (2), artoheterophyllin C (3), and artoheterophyllin D (4), together with 16 known compounds, were isolated from the ethanol extract of the twigs of A. heterophyllus. The structures of compounds 1-4 were elucidated by spectroscopic analysis. However, the four new compounds did not show significant inhibitory activities against mushroom tyrosinase compared to kojic acid. It was found that similar compounds, such as norartocarpetin and artocarpesin in the twigs and woods of A. heterophyllus, contributed to their tyrosinase inhibitory activity. © 2009 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcauen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_US
dc.subject.meshAgaricales - Enzymologyen_US
dc.subject.meshArtocarpus - Chemistryen_US
dc.subject.meshFungal Proteins - Antagonists & Inhibitorsen_US
dc.subject.meshMonophenol Monooxygenase - Antagonists & Inhibitorsen_US
dc.subject.meshPeptides - Chemistryen_US
dc.subject.meshPlant Bark - Chemistryen_US
dc.subject.meshPlant Extracts - Chemistryen_US
dc.subject.meshPlant Roots - Chemistryen_US
dc.titleChemical components and tyrosinase inhibitors from the twigs of Artocarpus heterophyllusen_US
dc.typeArticleen_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/jf9014685en_US
dc.identifier.pmid19588925-
dc.identifier.scopuseid_2-s2.0-68249108904en_US
dc.identifier.hkuros163921-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-68249108904&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume57en_US
dc.identifier.issue15en_US
dc.identifier.spage6649en_US
dc.identifier.epage6655en_US
dc.identifier.isiWOS:000268537300024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZheng, ZP=8451746600en_US
dc.identifier.scopusauthoridChen, S=41360899900en_US
dc.identifier.scopusauthoridWang, S=22136742300en_US
dc.identifier.scopusauthoridWang, XC=35206803200en_US
dc.identifier.scopusauthoridCheng, KW=12141247000en_US
dc.identifier.scopusauthoridWu, JJ=8298828200en_US
dc.identifier.scopusauthoridYang, D=41362136400en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US

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