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Article: Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish

TitleWaterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish
Authors
Issue Date2009
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/aquatox
Citation
Aquatic Toxicology, 2009, v. 93 n. 2-3, p. 131-137 How to Cite?
AbstractFluorotelomer alcohols (FTOHs) have shown estrogenic activity in vitro and in vivo, but the mechanism of this activity is not known. In this study, 18-week-old zebrafish (Danio rerio) were exposed to 0, 0.03, 0.3 and 3.0 mg/l 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) for 7 days, and the effects on plasma sex hormone levels were measured followed by use of real-time PCR to examine selected gene expression in hypothalamic-pituitary-gonadal (HPG) axis and liver. Exposure to 6:2 FTOH significantly increased plasma estradiol (E2) and testosterone (T) levels in both males and females. Furthermore, the ratio of T/E2 was reduced in females while increased in males. In females, the increase of E2 was accompanied by up-regulated hepatic estrogenic receptor α (ERα) and vitellogenin (VTG1 and VTG3) expression. In males, the elevation of the T level is consistent with the up-regulation of cytochrome P450 c17α-hydroxylase, 17, 20-lase (CYP17) and the down-regulation of cytochrome P450 aromatase A (CYP19A). The present study demonstrated that waterborne exposure to 6:2 FTOH alter plasma sex hormone levels and the ratio of T/E2, as well as the transcriptional profiles of some genes in the HPG axis and liver. The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. © 2009 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179138
ISSN
2015 Impact Factor: 3.557
2015 SCImago Journal Rankings: 1.671
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Cen_US
dc.contributor.authorYu, Len_US
dc.contributor.authorDeng, Jen_US
dc.contributor.authorLam, PKSen_US
dc.contributor.authorWu, RSSen_US
dc.contributor.authorZhou, Ben_US
dc.date.accessioned2012-12-19T09:52:17Z-
dc.date.available2012-12-19T09:52:17Z-
dc.date.issued2009en_US
dc.identifier.citationAquatic Toxicology, 2009, v. 93 n. 2-3, p. 131-137en_US
dc.identifier.issn0166-445Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/179138-
dc.description.abstractFluorotelomer alcohols (FTOHs) have shown estrogenic activity in vitro and in vivo, but the mechanism of this activity is not known. In this study, 18-week-old zebrafish (Danio rerio) were exposed to 0, 0.03, 0.3 and 3.0 mg/l 1H,1H,2H,2H-perfluorooctan-1-ol (6:2 FTOH) for 7 days, and the effects on plasma sex hormone levels were measured followed by use of real-time PCR to examine selected gene expression in hypothalamic-pituitary-gonadal (HPG) axis and liver. Exposure to 6:2 FTOH significantly increased plasma estradiol (E2) and testosterone (T) levels in both males and females. Furthermore, the ratio of T/E2 was reduced in females while increased in males. In females, the increase of E2 was accompanied by up-regulated hepatic estrogenic receptor α (ERα) and vitellogenin (VTG1 and VTG3) expression. In males, the elevation of the T level is consistent with the up-regulation of cytochrome P450 c17α-hydroxylase, 17, 20-lase (CYP17) and the down-regulation of cytochrome P450 aromatase A (CYP19A). The present study demonstrated that waterborne exposure to 6:2 FTOH alter plasma sex hormone levels and the ratio of T/E2, as well as the transcriptional profiles of some genes in the HPG axis and liver. The results suggested that FTOHs may disturb fish reproduction through endocrine disrupted activity. © 2009 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/aquatoxen_US
dc.relation.ispartofAquatic Toxicologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEndocrine Disruptors - Toxicityen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshEstradiol - Blooden_US
dc.subject.meshEstrogens - Toxicityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorocarbons - Toxicityen_US
dc.subject.meshGene Expression - Drug Effectsen_US
dc.subject.meshGonadal Steroid Hormones - Blooden_US
dc.subject.meshHypothalamo-Hypophyseal System - Metabolismen_US
dc.subject.meshLiver - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshTestosterone - Blooden_US
dc.subject.meshTranscription, Genetic - Drug Effectsen_US
dc.subject.meshWater Pollutants, Chemical - Toxicityen_US
dc.subject.meshZebrafish - Blood - Genetics - Metabolismen_US
dc.titleWaterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafishen_US
dc.typeArticleen_US
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_US
dc.identifier.authorityWu, RSS=rp01398en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.aquatox.2009.04.005en_US
dc.identifier.pmid19443055-
dc.identifier.scopuseid_2-s2.0-67349250916en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349250916&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume93en_US
dc.identifier.issue2-3en_US
dc.identifier.spage131en_US
dc.identifier.epage137en_US
dc.identifier.isiWOS:000268412600006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLiu, C=8318316300en_US
dc.identifier.scopusauthoridYu, L=37022805800en_US
dc.identifier.scopusauthoridDeng, J=35304700000en_US
dc.identifier.scopusauthoridLam, PKS=7202365776en_US
dc.identifier.scopusauthoridWu, RSS=7402945079en_US
dc.identifier.scopusauthoridZhou, B=7401906781en_US
dc.identifier.citeulike4994487-

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