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Article: Dietary fat concentration influences the effects of trans-10, cis-12 conjugated linoleic acid on temporal patterns of energy Intake and Hypothalamic expression of appetite-controlling genes in Mice

TitleDietary fat concentration influences the effects of trans-10, cis-12 conjugated linoleic acid on temporal patterns of energy Intake and Hypothalamic expression of appetite-controlling genes in Mice
Authors
Issue Date2009
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 2009, v. 139 n. 1, p. 145-151 How to Cite?
AbstractThis study tested the hypothesis that the effect of trans-10, c/s-12 conjugated linoleic acid (t10, c12 CLA) on energy intake (EI) and body weight (BW)/composition is confounded by dietary fat concentration and involves hypothalamic appetite-controlling mechanisms. ICR mice received low-fat (LF; 5g/100g) or high-fat (HF;30g/100g) diets, with or without 0.5 g/100 g t10, c12 CLA (>98% pure) for 27 d. By d 13, BW and cumulative EI of the mice fed CLA supplemented LF diet (LF/CLA) were 6.6 and 23.6% lower, respectively, than the LF mice. In the subsequent 14 d, their EI rebounded and did not differ from the LF group. BW and EI did not differ between the HF and CLA supplemented HF (HF/CLA) groups. Hypothalamic pro-opiomelanocortin (POMC) mRNA expression was elevated (P = 0.031) on d 13 but suppressed (P< 0.001) on d 27 due to CLA treatment. CLA also suppressed AMP-activated protein kinase α2 expression. Mice in Expt. 2 received the LF diet, the LF/CLA, or were pair-fed the LF diet to the EI of the CLA group (LF/PF). LF/CLA and LF/PF mice did not differ in the hypothalamic POMC:neuropeptide Y expression ratio on d 13, but it was significantly lower in the LF/PF group on d 27. We conclude that the habitual dietary fat concentration influences the magnitude of weight loss induced by dietary t10, c12 CLA. The effect is in part independent of EI. Hypothalamic neuropeptides and nutrient sensing mechanisms may play a role. © 2009 American Society for Nutrition.
Persistent Identifierhttp://hdl.handle.net/10722/179113
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, MHHen_US
dc.contributor.authorTse, IMYen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2012-12-19T09:52:04Z-
dc.date.available2012-12-19T09:52:04Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Nutrition, 2009, v. 139 n. 1, p. 145-151en_US
dc.identifier.issn0022-3166en_US
dc.identifier.urihttp://hdl.handle.net/10722/179113-
dc.description.abstractThis study tested the hypothesis that the effect of trans-10, c/s-12 conjugated linoleic acid (t10, c12 CLA) on energy intake (EI) and body weight (BW)/composition is confounded by dietary fat concentration and involves hypothalamic appetite-controlling mechanisms. ICR mice received low-fat (LF; 5g/100g) or high-fat (HF;30g/100g) diets, with or without 0.5 g/100 g t10, c12 CLA (>98% pure) for 27 d. By d 13, BW and cumulative EI of the mice fed CLA supplemented LF diet (LF/CLA) were 6.6 and 23.6% lower, respectively, than the LF mice. In the subsequent 14 d, their EI rebounded and did not differ from the LF group. BW and EI did not differ between the HF and CLA supplemented HF (HF/CLA) groups. Hypothalamic pro-opiomelanocortin (POMC) mRNA expression was elevated (P = 0.031) on d 13 but suppressed (P< 0.001) on d 27 due to CLA treatment. CLA also suppressed AMP-activated protein kinase α2 expression. Mice in Expt. 2 received the LF diet, the LF/CLA, or were pair-fed the LF diet to the EI of the CLA group (LF/PF). LF/CLA and LF/PF mice did not differ in the hypothalamic POMC:neuropeptide Y expression ratio on d 13, but it was significantly lower in the LF/PF group on d 27. We conclude that the habitual dietary fat concentration influences the magnitude of weight loss induced by dietary t10, c12 CLA. The effect is in part independent of EI. Hypothalamic neuropeptides and nutrient sensing mechanisms may play a role. © 2009 American Society for Nutrition.en_US
dc.languageengen_US
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_US
dc.relation.ispartofJournal of Nutritionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAppetite - Physiologyen_US
dc.subject.meshDietary Fats - Administration & Dosage - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFeeding Behavioren_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulation - Drug Effects - Physiologyen_US
dc.subject.meshHypothalamus - Metabolismen_US
dc.subject.meshLinoleic Acids, Conjugated - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Icren_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshWeight Gain - Drug Effectsen_US
dc.titleDietary fat concentration influences the effects of trans-10, cis-12 conjugated linoleic acid on temporal patterns of energy Intake and Hypothalamic expression of appetite-controlling genes in Miceen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3945/jn.108.093849en_US
dc.identifier.pmid19056663-
dc.identifier.scopuseid_2-s2.0-58649117155en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58649117155&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume139en_US
dc.identifier.issue1en_US
dc.identifier.spage145en_US
dc.identifier.epage151en_US
dc.identifier.eissn1541-6100-
dc.identifier.isiWOS:000261777100025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSo, MHH=36719005000en_US
dc.identifier.scopusauthoridTse, IMY=14635211700en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US

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