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Article: D-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-A y mice

TitleD-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-A y mice
Authors
KeywordsAntidiabetic Activity
Blood Glucose
Dci
Steaming
Tartary Buckwheat
Issue Date2008
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
Citation
Journal Of Agricultural And Food Chemistry, 2008, v. 56 n. 21, p. 10027-10031 How to Cite?
AbstractD-chiro-inositol (DCI) is an active compound in tartary buckwheat [Fagopyrum tataricum (L) Gaench] with an insulin-like bioactivity. The present study was performed to (i) prepare DCI-enriched tartary buckwheat bran extract (TBBE), (ii) evaluate its acute toxicity in mice, and (iii) examine its blood glucose lowering activity in diabetic mice. It was found that steaming buckwheat bran in an autoclave at 1.6 MPa and 120 °C for 60 min could significantly enrich the DCI level in TBBE from 0.03 to 0.22% and further to 22% after passage of the TBBE through activated carbon and ion exchange resins. An acute toxicity test demonstrated that the LD 50 of TBBE was >20 g/kg of body weight in mice, suggesting that TBBE was in general nontoxic and safe in mice. Male KK-A y mice (type 2 diabetic) and C57BL/6 mice (the control) were used to investigate the antidiabetic activity of TBBE. In KK-A y mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice. In addition, KK-A y mice showed an obvious decrease in insulin immunoreactivity in the pancreas. The present study clearly demonstrated that oral administration of DCI-enriched TBBE could lower plasma glucose, C-peptide, glucagon, triglyceride, and BUN, improve glucose tolerance, and enhance insulin immunoreactivity in KK-A y mice. © 2008 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/179111
ISSN
2015 Impact Factor: 2.857
2015 SCImago Journal Rankings: 1.246
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYao, Yen_US
dc.contributor.authorShan, Fen_US
dc.contributor.authorBian, Jen_US
dc.contributor.authorChen, Fen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorRen, Gen_US
dc.date.accessioned2012-12-19T09:52:04Z-
dc.date.available2012-12-19T09:52:04Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2008, v. 56 n. 21, p. 10027-10031en_US
dc.identifier.issn0021-8561en_US
dc.identifier.urihttp://hdl.handle.net/10722/179111-
dc.description.abstractD-chiro-inositol (DCI) is an active compound in tartary buckwheat [Fagopyrum tataricum (L) Gaench] with an insulin-like bioactivity. The present study was performed to (i) prepare DCI-enriched tartary buckwheat bran extract (TBBE), (ii) evaluate its acute toxicity in mice, and (iii) examine its blood glucose lowering activity in diabetic mice. It was found that steaming buckwheat bran in an autoclave at 1.6 MPa and 120 °C for 60 min could significantly enrich the DCI level in TBBE from 0.03 to 0.22% and further to 22% after passage of the TBBE through activated carbon and ion exchange resins. An acute toxicity test demonstrated that the LD 50 of TBBE was >20 g/kg of body weight in mice, suggesting that TBBE was in general nontoxic and safe in mice. Male KK-A y mice (type 2 diabetic) and C57BL/6 mice (the control) were used to investigate the antidiabetic activity of TBBE. In KK-A y mice, the blood glucose, plasma C-peptide, glucagon, total cholesterol, triglyceride, and blood urea nitrogen (BUN) levels were significantly higher than those in the C57BL/6 mice. In addition, KK-A y mice showed an obvious decrease in insulin immunoreactivity in the pancreas. The present study clearly demonstrated that oral administration of DCI-enriched TBBE could lower plasma glucose, C-peptide, glucagon, triglyceride, and BUN, improve glucose tolerance, and enhance insulin immunoreactivity in KK-A y mice. © 2008 American Chemical Society.en_US
dc.languageengen_US
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcauen_US
dc.relation.ispartofJournal of Agricultural and Food Chemistryen_US
dc.subjectAntidiabetic Activityen_US
dc.subjectBlood Glucoseen_US
dc.subjectDcien_US
dc.subjectSteamingen_US
dc.subjectTartary Buckwheaten_US
dc.titleD-chiro-inositol-enriched tartary buckwheat bran extract lowers the blood glucose level in KK-A y miceen_US
dc.typeArticleen_US
dc.identifier.emailChen, F: sfchen@hku.hken_US
dc.identifier.emailWang, M: mfwang@hku.hken_US
dc.identifier.authorityChen, F=rp00672en_US
dc.identifier.authorityWang, M=rp00800en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1021/jf801879men_US
dc.identifier.pmid18921966-
dc.identifier.scopuseid_2-s2.0-58149333561en_US
dc.identifier.hkuros163908-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149333561&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue21en_US
dc.identifier.spage10027en_US
dc.identifier.epage10031en_US
dc.identifier.isiWOS:000260675600044-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYao, Y=35308337100en_US
dc.identifier.scopusauthoridShan, F=36864171700en_US
dc.identifier.scopusauthoridBian, J=7103200051en_US
dc.identifier.scopusauthoridChen, F=7404907980en_US
dc.identifier.scopusauthoridWang, M=7406691844en_US
dc.identifier.scopusauthoridRen, G=7103325357en_US

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