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Conference Paper: A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression

TitleA functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression
Authors
Issue Date2008
Citation
The 8th International Symposium on VIP, PACAP and Related Peptides. Symposium dedicated to the memory of Akira Arimura, Manchester, VT, 3-8 September 2007. In Journal Of Molecular Neuroscience, 2008, v. 36 n. 1-3, p. 125-131 How to Cite?
AbstractSecretin is a peptide hormone playing multiple functions in the brain-gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals. © 2008 Humana Press.
Persistent Identifierhttp://hdl.handle.net/10722/179109
ISSN
2015 Impact Factor: 2.352
2015 SCImago Journal Rankings: 0.988
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, LTOen_US
dc.contributor.authorLam, IPYen_US
dc.contributor.authorChow, BKCen_US
dc.date.accessioned2012-12-19T09:52:03Z-
dc.date.available2012-12-19T09:52:03Z-
dc.date.issued2008en_US
dc.identifier.citationThe 8th International Symposium on VIP, PACAP and Related Peptides. Symposium dedicated to the memory of Akira Arimura, Manchester, VT, 3-8 September 2007. In Journal Of Molecular Neuroscience, 2008, v. 36 n. 1-3, p. 125-131en_US
dc.identifier.issn0895-8696en_US
dc.identifier.urihttp://hdl.handle.net/10722/179109-
dc.description.abstractSecretin is a peptide hormone playing multiple functions in the brain-gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals. © 2008 Humana Press.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Molecular Neuroscienceen_US
dc.subject.mesh5' Flanking Region - Geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshDown-Regulationen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMinisatellite Repeatsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshSecretin - Genetics - Metabolismen_US
dc.subject.meshSequence Alignmenten_US
dc.titleA functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expressionen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, LTO: ltolee2@hkucc.hku.hken_US
dc.identifier.emailChow, BKC: bkcc@hku.hken_US
dc.identifier.authorityLee, LTO=rp00727en_US
dc.identifier.authorityChow, BKC=rp00681en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12031-008-9083-5en_US
dc.identifier.pmid18566919-
dc.identifier.scopuseid_2-s2.0-58149089287en_US
dc.identifier.hkuros156841-
dc.identifier.hkuros181127-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58149089287&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue1-3en_US
dc.identifier.spage125en_US
dc.identifier.epage131en_US
dc.identifier.isiWOS:000261180200016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, LTO=8367269000en_US
dc.identifier.scopusauthoridLam, IPY=14050702700en_US
dc.identifier.scopusauthoridChow, BKC=7102826193en_US

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