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Article: CYP17 MspA1 polymorphism and age at menarche: A meta-analysis

TitleCYP17 MspA1 polymorphism and age at menarche: A meta-analysis
Authors
Issue Date2008
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
Citation
Disease Markers, 2008, v. 25 n. 2, p. 87-95 How to Cite?
AbstractObjective: Literature data on the effects of CYP17 MspA1 polymorphism on age at menarche (AAM) are inconsistent. To reexamine this controversy, we performed a meta-analysis. Study design: In total 16 studies containing more than 11000 individuals of various ethnicities were selected for the analyses. For 11 case-control studies, odds ratio (OR) was employed to evaluate the risk of late AAM for each study, using homozygote at the wild-type allele as a control group. For the 5 studies with continuous outcomes, the effect size was estimated using the Hedges' adjusted g, which is calculated based on the standardized mean difference between groups of subjects with early and late AAM. Results: We did not find evidence for association of the MspA1 polymorphism with AAM in the combined case-control sample with mixed ethnic background (OR = 1.03, 95% CI: 0.90-1.18, P = 0.66), in the monoethnic case-control sample of Caucasian females (OR = 1.09, 95% CI: 0.99-1.20, P = 0.08) and in the combined sample with continuous traits (Hedges' g = 0.33 and -0.041, 95% CI: -0.14-0.80 and -0.18-0.10, P values 0.17 and 0.56 for the pooled population sample and monoethnic sample of Caucasian females, respectively). Conclusion: Our study showed that CYP17 MspA1 polymorphism was not a significant independent risk factor of AAM. Further studies are needed to clarify the effects of the interaction between this gene and other genetic and/or environment factors on AAM. © 2008 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179096
ISSN
2015 Impact Factor: 2.137
2015 SCImago Journal Rankings: 0.774
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPei, YFen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorDeng, HWen_US
dc.contributor.authorDvornyk, Ven_US
dc.date.accessioned2012-12-19T09:51:57Z-
dc.date.available2012-12-19T09:51:57Z-
dc.date.issued2008en_US
dc.identifier.citationDisease Markers, 2008, v. 25 n. 2, p. 87-95en_US
dc.identifier.issn0278-0240en_US
dc.identifier.urihttp://hdl.handle.net/10722/179096-
dc.description.abstractObjective: Literature data on the effects of CYP17 MspA1 polymorphism on age at menarche (AAM) are inconsistent. To reexamine this controversy, we performed a meta-analysis. Study design: In total 16 studies containing more than 11000 individuals of various ethnicities were selected for the analyses. For 11 case-control studies, odds ratio (OR) was employed to evaluate the risk of late AAM for each study, using homozygote at the wild-type allele as a control group. For the 5 studies with continuous outcomes, the effect size was estimated using the Hedges' adjusted g, which is calculated based on the standardized mean difference between groups of subjects with early and late AAM. Results: We did not find evidence for association of the MspA1 polymorphism with AAM in the combined case-control sample with mixed ethnic background (OR = 1.03, 95% CI: 0.90-1.18, P = 0.66), in the monoethnic case-control sample of Caucasian females (OR = 1.09, 95% CI: 0.99-1.20, P = 0.08) and in the combined sample with continuous traits (Hedges' g = 0.33 and -0.041, 95% CI: -0.14-0.80 and -0.18-0.10, P values 0.17 and 0.56 for the pooled population sample and monoethnic sample of Caucasian females, respectively). Conclusion: Our study showed that CYP17 MspA1 polymorphism was not a significant independent risk factor of AAM. Further studies are needed to clarify the effects of the interaction between this gene and other genetic and/or environment factors on AAM. © 2008 - IOS Press and the authors. All rights reserved.en_US
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.phpen_US
dc.relation.ispartofDisease Markersen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMenarche - Geneticsen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSteroid 17-Alpha-Hydroxylase - Geneticsen_US
dc.titleCYP17 MspA1 polymorphism and age at menarche: A meta-analysisen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1155/2008/403982-
dc.identifier.pmid18957719-
dc.identifier.pmcidPMC2748958-
dc.identifier.scopuseid_2-s2.0-55449130235en_US
dc.identifier.hkuros153457-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-55449130235&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue2en_US
dc.identifier.spage87en_US
dc.identifier.epage95en_US
dc.identifier.isiWOS:000260777700003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridPei, YF=35345715100en_US
dc.identifier.scopusauthoridZhang, L=8508954500en_US
dc.identifier.scopusauthoridDeng, HW=7401775190en_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US

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