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Article: Algal lectins for potential prevention of HIV transmission

TitleAlgal lectins for potential prevention of HIV transmission
Authors
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htm
Citation
Current Medicinal Chemistry, 2008, v. 15 n. 11, p. 1096-1104 How to Cite?
AbstractA number of lectins that bind high-mannose carbohydrates on the surface of the envelopes of virus has been found to have antiviral activity. In particular, some algal lectins such as Cyanovirin-N, Microcystis viridis lectin, Scytovirin, Griffithsin and Oscillatoria agardhii agglutinin, exhibit high anti-HIV activity, and provide an alternative route to prevention of HIV transmission. This review focuses on the structural property, antiviral activity and possible mechanism of these lectins, and future challenges for potential prophylaclic or therapeutic applications are also discussed. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179067
ISSN
2015 Impact Factor: 3.455
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, Yen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorChen, Gen_US
dc.contributor.authorWei, Den_US
dc.contributor.authorChen, Fen_US
dc.date.accessioned2012-12-19T09:51:45Z-
dc.date.available2012-12-19T09:51:45Z-
dc.date.issued2008en_US
dc.identifier.citationCurrent Medicinal Chemistry, 2008, v. 15 n. 11, p. 1096-1104en_US
dc.identifier.issn0929-8673en_US
dc.identifier.urihttp://hdl.handle.net/10722/179067-
dc.description.abstractA number of lectins that bind high-mannose carbohydrates on the surface of the envelopes of virus has been found to have antiviral activity. In particular, some algal lectins such as Cyanovirin-N, Microcystis viridis lectin, Scytovirin, Griffithsin and Oscillatoria agardhii agglutinin, exhibit high anti-HIV activity, and provide an alternative route to prevention of HIV transmission. This review focuses on the structural property, antiviral activity and possible mechanism of these lectins, and future challenges for potential prophylaclic or therapeutic applications are also discussed. © 2008 Bentham Science Publishers Ltd.en_US
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmc/index.htmen_US
dc.relation.ispartofCurrent Medicinal Chemistryen_US
dc.subject.meshAlgal Proteins - Chemistry - Therapeutic Useen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Transmission, Infectious - Prevention & Controlen_US
dc.subject.meshDrug Evaluation, Preclinicalen_US
dc.subject.meshHiv - Drug Effectsen_US
dc.subject.meshHiv Infections - Drug Therapy - Transmissionen_US
dc.subject.meshHumansen_US
dc.subject.meshLectins - Chemistry - Therapeutic Useen_US
dc.subject.meshModels, Molecularen_US
dc.titleAlgal lectins for potential prevention of HIV transmissionen_US
dc.typeArticleen_US
dc.identifier.emailChen, F: sfchen@hku.hken_US
dc.identifier.authorityChen, F=rp00672en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2174/092986708784221421en_US
dc.identifier.pmid18473805-
dc.identifier.scopuseid_2-s2.0-48949117589en_US
dc.identifier.hkuros147697-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48949117589&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue11en_US
dc.identifier.spage1096en_US
dc.identifier.epage1104en_US
dc.identifier.isiWOS:000256616400004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, Y=36160277100en_US
dc.identifier.scopusauthoridZhang, X=16044335800en_US
dc.identifier.scopusauthoridChen, G=35309532100en_US
dc.identifier.scopusauthoridWei, D=24472144100en_US
dc.identifier.scopusauthoridChen, F=7404907980en_US
dc.identifier.citeulike2750267-

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