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Article: Lack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects

TitleLack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects
Authors
Issue Date2008
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.asp
Citation
Free Radical Research, 2008, v. 42 n. 5, p. 514-522 How to Cite?
AbstractVitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator, possibly by increasing nitric oxide bioavailability. This study examined the antioxidant and vascular effects of a single large oral dose of vitamin C in 26 healthy human volunteers. Haemodynamic and oxidative DNA and lipid damage markers were measured for 8 h following an oral dose of 2 g vitamin C or placebo. Vitamin C had no effect on vasodilation (measured by augmentation index (mean change = 0.04%, 90% CI= -2.20% to 2.28%) or forearm blood flow (-0.19%/min (-0.68, 0.30)), in comparison to placebo) or on several markers of oxidative stress including DNA base oxidation products in blood cells, 8-hydroxy-2′-deoxyguanosine (8O HdG) in urine (0.068 (-0.009, 0.144)) or urinary or plasma total F 2-isoprostanes (-0.005 ng/ml (-0.021, 0.010), -0.153 ng/mg (-0.319, 0.014), respectively).
Persistent Identifierhttp://hdl.handle.net/10722/179063
ISSN
2015 Impact Factor: 2.949
2015 SCImago Journal Rankings: 1.159
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKelly, Ren_US
dc.contributor.authorPoo Yeo, Ken_US
dc.contributor.authorIsaac, Hen_US
dc.contributor.authorLee, CYen_US
dc.contributor.authorHuang, SHen_US
dc.contributor.authorTeng, Len_US
dc.contributor.authorHalliwell, Ben_US
dc.contributor.authorWise, Sen_US
dc.date.accessioned2012-12-19T09:51:43Z-
dc.date.available2012-12-19T09:51:43Z-
dc.date.issued2008en_US
dc.identifier.citationFree Radical Research, 2008, v. 42 n. 5, p. 514-522en_US
dc.identifier.issn1071-5762en_US
dc.identifier.urihttp://hdl.handle.net/10722/179063-
dc.description.abstractVitamin C is a potent antioxidant in vitro and has been reported to act as a vasodilator, possibly by increasing nitric oxide bioavailability. This study examined the antioxidant and vascular effects of a single large oral dose of vitamin C in 26 healthy human volunteers. Haemodynamic and oxidative DNA and lipid damage markers were measured for 8 h following an oral dose of 2 g vitamin C or placebo. Vitamin C had no effect on vasodilation (measured by augmentation index (mean change = 0.04%, 90% CI= -2.20% to 2.28%) or forearm blood flow (-0.19%/min (-0.68, 0.30)), in comparison to placebo) or on several markers of oxidative stress including DNA base oxidation products in blood cells, 8-hydroxy-2′-deoxyguanosine (8O HdG) in urine (0.068 (-0.009, 0.144)) or urinary or plasma total F 2-isoprostanes (-0.005 ng/ml (-0.021, 0.010), -0.153 ng/mg (-0.319, 0.014), respectively).en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10715762.aspen_US
dc.relation.ispartofFree Radical Researchen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAntioxidants - Metabolismen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshAscorbic Acid - Metabolism - Pharmacologyen_US
dc.subject.meshBiological Markers - Metabolismen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemodynamicsen_US
dc.subject.meshHumansen_US
dc.subject.meshLipids - Chemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshPlacebosen_US
dc.subject.meshVasodilator Agents - Pharmacologyen_US
dc.titleLack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjectsen_US
dc.typeArticleen_US
dc.identifier.emailLee, CY: jettylee@hku.hken_US
dc.identifier.authorityLee, CY=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/10715760802087431en_US
dc.identifier.pmid18484415-
dc.identifier.scopuseid_2-s2.0-46649098894en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46649098894&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume42en_US
dc.identifier.issue5en_US
dc.identifier.spage514en_US
dc.identifier.epage522en_US
dc.identifier.isiWOS:000256583100012-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridKelly, R=8503159700en_US
dc.identifier.scopusauthoridPoo Yeo, K=12775057300en_US
dc.identifier.scopusauthoridIsaac, H=13103867700en_US
dc.identifier.scopusauthoridLee, CY=13104265200en_US
dc.identifier.scopusauthoridHuang, SH=8367750600en_US
dc.identifier.scopusauthoridTeng, L=12762461000en_US
dc.identifier.scopusauthoridHalliwell, B=7101878919en_US
dc.identifier.scopusauthoridWise, S=7202622558en_US

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