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Article: Preparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography

TitlePreparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatography
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chroma
Citation
Journal Of Chromatography A, 2004, v. 1047 n. 2, p. 249-253 How to Cite?
AbstractLigusticum chuanxiong Hort has been used widely in traditional medicines for the treatment of various kinds of disorders such as cardiovascular and cerebrovascular diseases. High-speed counter-current chromatography was applied to the isolation and purification of the bioactive component chuanxiongzine from L. chuanxiong Hort. The crude chuanxiongzine was obtained by extraction with ethanol from the dried roots of L. chuanxiong Hort under sonication. Preparative high-speed counter-current chromatography with a two-phase solvent system composed of n-hexane-ethyl acetate-ethanol-water (5:5:3:7, v/v) was successfully performed yielding 11.5 mg chuanxiongzine at 96.8% purity from 300 mg of the crude extract (4.2% chuanxiongzine) with the recovery of 91% in a one-step separation. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179055
ISSN
2015 Impact Factor: 3.926
2015 SCImago Journal Rankings: 1.774
References

 

DC FieldValueLanguage
dc.contributor.authorLi, HBen_US
dc.contributor.authorChen, Fen_US
dc.date.accessioned2012-12-19T09:51:41Z-
dc.date.available2012-12-19T09:51:41Z-
dc.date.issued2004en_US
dc.identifier.citationJournal Of Chromatography A, 2004, v. 1047 n. 2, p. 249-253en_US
dc.identifier.issn0021-9673en_US
dc.identifier.urihttp://hdl.handle.net/10722/179055-
dc.description.abstractLigusticum chuanxiong Hort has been used widely in traditional medicines for the treatment of various kinds of disorders such as cardiovascular and cerebrovascular diseases. High-speed counter-current chromatography was applied to the isolation and purification of the bioactive component chuanxiongzine from L. chuanxiong Hort. The crude chuanxiongzine was obtained by extraction with ethanol from the dried roots of L. chuanxiong Hort under sonication. Preparative high-speed counter-current chromatography with a two-phase solvent system composed of n-hexane-ethyl acetate-ethanol-water (5:5:3:7, v/v) was successfully performed yielding 11.5 mg chuanxiongzine at 96.8% purity from 300 mg of the crude extract (4.2% chuanxiongzine) with the recovery of 91% in a one-step separation. © 2004 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/chromaen_US
dc.relation.ispartofJournal of Chromatography Aen_US
dc.rightsJournal of Chromatography A. Copyright © Elsevier BV.-
dc.subject.meshCountercurrent Distribution - Methodsen_US
dc.subject.meshDrugs, Chinese Herbal - Chemistryen_US
dc.subject.meshPlant Extracts - Isolation & Purificationen_US
dc.subject.meshPlants, Medicinal - Chemistryen_US
dc.subject.meshPyrazines - Isolation & Purificationen_US
dc.titlePreparative isolation and purification of chuanxiongzine from the medicinal plant Ligusticum chuanxiong by high-speed counter-current chromatographyen_US
dc.typeArticleen_US
dc.identifier.emailChen, F: sfchen@hku.hken_US
dc.identifier.authorityChen, F=rp00672en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.chroma.2004.07.006en_US
dc.identifier.pmid15460256-
dc.identifier.scopuseid_2-s2.0-4444256863en_US
dc.identifier.hkuros105985-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4444256863&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1047en_US
dc.identifier.issue2en_US
dc.identifier.spage249en_US
dc.identifier.epage253en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, HB=25649944400en_US
dc.identifier.scopusauthoridChen, F=7404907980en_US

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