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Article: Ubiquitin system in male reproductive and its relevance to contraception

TitleUbiquitin system in male reproductive and its relevance to contraception
Authors
KeywordsCell Junctions
Contraception
Reproduction
Spermatogenesis
Ubiquitination
Issue Date2008
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmciema/index.htm
Citation
Immunology, Endocrine And Metabolic Agents In Medicinal Chemistry, 2008, v. 8 n. 1, p. 14-19 How to Cite?
AbstractThe post-translational modification of proteins by covalent attachment of ubiquitin molecules targets protein for degradation by 26S proteasome composed of a 20S core unit capped with one 19S regulatory complex on each side. Such event plays a key role in numerous cellular functions including spermatogenesis. It is conceivable that ubiquitination is involved in all phases of spermatogenesis and its destinated functions control various cellular activities in the testis, ranging from the mitotic spindle formation in germ cells to the structural formation of the spermatid flagella. In this review, we aim to summarize the recent findings in the study of ubiquitination in the testis. It also highlights specific areas for future research toward a better understanding of the precise physiological relationship between ubiquitin-mediated proteolysis and spermatogenesis. Furthermore, a thorough understanding of this system that can lead to developing new approaches for male contraception is discussed. © 2008 Bentham Science Publishers Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/179053
ISSN
2015 SCImago Journal Rankings: 0.135
References

 

DC FieldValueLanguage
dc.contributor.authorLui, WYen_US
dc.contributor.authorLee, WMen_US
dc.date.accessioned2012-12-19T09:51:40Z-
dc.date.available2012-12-19T09:51:40Z-
dc.date.issued2008en_US
dc.identifier.citationImmunology, Endocrine And Metabolic Agents In Medicinal Chemistry, 2008, v. 8 n. 1, p. 14-19en_US
dc.identifier.issn1871-5222en_US
dc.identifier.urihttp://hdl.handle.net/10722/179053-
dc.description.abstractThe post-translational modification of proteins by covalent attachment of ubiquitin molecules targets protein for degradation by 26S proteasome composed of a 20S core unit capped with one 19S regulatory complex on each side. Such event plays a key role in numerous cellular functions including spermatogenesis. It is conceivable that ubiquitination is involved in all phases of spermatogenesis and its destinated functions control various cellular activities in the testis, ranging from the mitotic spindle formation in germ cells to the structural formation of the spermatid flagella. In this review, we aim to summarize the recent findings in the study of ubiquitination in the testis. It also highlights specific areas for future research toward a better understanding of the precise physiological relationship between ubiquitin-mediated proteolysis and spermatogenesis. Furthermore, a thorough understanding of this system that can lead to developing new approaches for male contraception is discussed. © 2008 Bentham Science Publishers Ltd.en_US
dc.languageengen_US
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.bentham.org/cmciema/index.htmen_US
dc.relation.ispartofImmunology, Endocrine and Metabolic Agents in Medicinal Chemistryen_US
dc.subjectCell Junctionsen_US
dc.subjectContraceptionen_US
dc.subjectReproductionen_US
dc.subjectSpermatogenesisen_US
dc.subjectUbiquitinationen_US
dc.titleUbiquitin system in male reproductive and its relevance to contraceptionen_US
dc.typeArticleen_US
dc.identifier.emailLui, WY: wylui@hku.hken_US
dc.identifier.emailLee, WM: hrszlwm@hku.hken_US
dc.identifier.authorityLui, WY=rp00756en_US
dc.identifier.authorityLee, WM=rp00728en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.2174/187152208783790688en_US
dc.identifier.scopuseid_2-s2.0-44149121236en_US
dc.identifier.hkuros146534-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44149121236&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.spage14en_US
dc.identifier.epage19en_US
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLui, WY=35220192400en_US
dc.identifier.scopusauthoridLee, WM=24799156600en_US

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