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Article: Elevated F 2-isoprostanes in thalassemic patients

TitleElevated F 2-isoprostanes in thalassemic patients
Authors
KeywordsF 2-Isoprostanes
Oxidative Stress
Thalassemia
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed
Citation
Free Radical Biology And Medicine, 2007, v. 43 n. 12, p. 1649-1655 How to Cite?
AbstractThis study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F 2-isoprostanes (F 2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F 2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F 2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H 2O 2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/179022
ISSN
2015 Impact Factor: 5.784
2015 SCImago Journal Rankings: 2.468
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMatayatsuk, Cen_US
dc.contributor.authorLee, CYJen_US
dc.contributor.authorKalpravidh, RWen_US
dc.contributor.authorSirankapracha, Pen_US
dc.contributor.authorWilairat, Pen_US
dc.contributor.authorFucharoen, Sen_US
dc.contributor.authorHalliwell, Ben_US
dc.date.accessioned2012-12-19T09:51:29Z-
dc.date.available2012-12-19T09:51:29Z-
dc.date.issued2007en_US
dc.identifier.citationFree Radical Biology And Medicine, 2007, v. 43 n. 12, p. 1649-1655en_US
dc.identifier.issn0891-5849en_US
dc.identifier.urihttp://hdl.handle.net/10722/179022-
dc.description.abstractThis study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F 2-isoprostanes (F 2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F 2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F 2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H 2O 2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomeden_US
dc.relation.ispartofFree Radical Biology and Medicineen_US
dc.subjectF 2-Isoprostanesen_US
dc.subjectOxidative Stressen_US
dc.subjectThalassemiaen_US
dc.titleElevated F 2-isoprostanes in thalassemic patientsen_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.freeradbiomed.2007.08.026en_US
dc.identifier.pmid18037130-
dc.identifier.scopuseid_2-s2.0-36248946663en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36248946663&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume43en_US
dc.identifier.issue12en_US
dc.identifier.spage1649en_US
dc.identifier.epage1655en_US
dc.identifier.isiWOS:000251670500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMatayatsuk, C=22958225700en_US
dc.identifier.scopusauthoridLee, CYJ=13104265200en_US
dc.identifier.scopusauthoridKalpravidh, RW=10642230200en_US
dc.identifier.scopusauthoridSirankapracha, P=6507380364en_US
dc.identifier.scopusauthoridWilairat, P=55399307100en_US
dc.identifier.scopusauthoridFucharoen, S=7103089590en_US
dc.identifier.scopusauthoridHalliwell, B=7101878919en_US

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