File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.freeradbiomed.2007.08.026
- Scopus: eid_2-s2.0-36248946663
- PMID: 18037130
- WOS: WOS:000251670500009
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Elevated F 2-isoprostanes in thalassemic patients
Title | Elevated F 2-isoprostanes in thalassemic patients |
---|---|
Authors | |
Keywords | F 2-Isoprostanes Oxidative Stress Thalassemia |
Issue Date | 2007 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed |
Citation | Free Radical Biology And Medicine, 2007, v. 43 n. 12, p. 1649-1655 How to Cite? |
Abstract | This study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F 2-isoprostanes (F 2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F 2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F 2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H 2O 2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/179022 |
ISSN | 2021 Impact Factor: 8.101 2020 SCImago Journal Rankings: 1.912 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Matayatsuk, C | en_US |
dc.contributor.author | Lee, CYJ | en_US |
dc.contributor.author | Kalpravidh, RW | en_US |
dc.contributor.author | Sirankapracha, P | en_US |
dc.contributor.author | Wilairat, P | en_US |
dc.contributor.author | Fucharoen, S | en_US |
dc.contributor.author | Halliwell, B | en_US |
dc.date.accessioned | 2012-12-19T09:51:29Z | - |
dc.date.available | 2012-12-19T09:51:29Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Free Radical Biology And Medicine, 2007, v. 43 n. 12, p. 1649-1655 | en_US |
dc.identifier.issn | 0891-5849 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/179022 | - |
dc.description.abstract | This study was aimed at investigating oxidative stress in thalassemic patients by measurement of the oxidative damage biomarker, F 2-isoprostanes (F 2-IsoPs), using gas chromatography-mass spectrometry. The results showed that the mean value of urinary F 2-IsoPs, normalized with creatinine, in the thalassemic group was significantly higher than that from healthy subjects (3.38 ± 2.15 ng/mg creatinine vs 0.86 ± 0.55 ng/mg creatinine, respectively), and the mean value of plasma total F 2-IsoPs in the thalassemic group was also significantly higher than that from healthy subjects (0.39 ± 0.15 ng/ml vs 0.18 ± 0.03 ng/ml, respectively). Serum ferritin, erythrocyte superoxide dismutase (SOD), glutathione peroxidase, glutathione, and TBARS levels after treatment of erythrocytes with H 2O 2 were also investigated, and serum ferritin and erythrocyte SOD levels were significantly higher in thalassemic patients. Our findings are consistent with oxidative stress in thalassemia patients. © 2007 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed | en_US |
dc.relation.ispartof | Free Radical Biology and Medicine | en_US |
dc.subject | F 2-Isoprostanes | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Thalassemia | en_US |
dc.title | Elevated F 2-isoprostanes in thalassemic patients | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lee, CYJ: jettylee@hku.hk | en_US |
dc.identifier.authority | Lee, CYJ=rp01511 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.freeradbiomed.2007.08.026 | en_US |
dc.identifier.pmid | 18037130 | - |
dc.identifier.scopus | eid_2-s2.0-36248946663 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-36248946663&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 43 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 1649 | en_US |
dc.identifier.epage | 1655 | en_US |
dc.identifier.isi | WOS:000251670500009 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Matayatsuk, C=22958225700 | en_US |
dc.identifier.scopusauthorid | Lee, CYJ=13104265200 | en_US |
dc.identifier.scopusauthorid | Kalpravidh, RW=10642230200 | en_US |
dc.identifier.scopusauthorid | Sirankapracha, P=6507380364 | en_US |
dc.identifier.scopusauthorid | Wilairat, P=55399307100 | en_US |
dc.identifier.scopusauthorid | Fucharoen, S=7103089590 | en_US |
dc.identifier.scopusauthorid | Halliwell, B=7101878919 | en_US |
dc.identifier.issnl | 0891-5849 | - |