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Article: Polymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females

TitlePolymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian females
Authors
Issue Date2006
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09513590.asp
Citation
Gynecological Endocrinology, 2006, v. 22 n. 10, p. 552-556 How to Cite?
AbstractWe tested association of four single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene (VDR) with age at surgical and natural menopause in a sample of Caucasians composed of 153 women with surgical and 260 with natural menopause. A significant association was observed between age at surgical menopause and two SNPs, rs1544410 (BsmI) and rs731236 (TaqI) (p < 0.05). For rs1544410, homozygotes of the minor allele, AA, had about two-fold higher risk of surgical menopause than homozygotes of the major allele, GG (95% confidence ratio (CI) 1.09-3.82). For rs731236, the CC subjects had a greater chance of surgical menopause than the TT subjects (odds ratio = 2.01, 95% CI 1.07-3.78). Since rs1544410 and rs731236 are in strong linkage disequilibrium, the haplotypes based on these two loci were also tested. The haplotype AC was highly significantly associated with age at surgical menopause (p = 0.008). Women with this haplotype had surgical menopause on average 2.8 years earlier than non-carriers. These results reveal the potential effect of the VDR gene on ovaries and uterus, and suggest that its SNPs can be used as predictors of genetic susceptibility for early surgical menopause and respective causal health problems. © 2006 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/178972
ISSN
2015 Impact Factor: 1.413
2015 SCImago Journal Rankings: 0.586
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorLong, JRen_US
dc.contributor.authorLiu, PYen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorRecker, RRen_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T09:51:10Z-
dc.date.available2012-12-19T09:51:10Z-
dc.date.issued2006en_US
dc.identifier.citationGynecological Endocrinology, 2006, v. 22 n. 10, p. 552-556en_US
dc.identifier.issn0951-3590en_US
dc.identifier.urihttp://hdl.handle.net/10722/178972-
dc.description.abstractWe tested association of four single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene (VDR) with age at surgical and natural menopause in a sample of Caucasians composed of 153 women with surgical and 260 with natural menopause. A significant association was observed between age at surgical menopause and two SNPs, rs1544410 (BsmI) and rs731236 (TaqI) (p < 0.05). For rs1544410, homozygotes of the minor allele, AA, had about two-fold higher risk of surgical menopause than homozygotes of the major allele, GG (95% confidence ratio (CI) 1.09-3.82). For rs731236, the CC subjects had a greater chance of surgical menopause than the TT subjects (odds ratio = 2.01, 95% CI 1.07-3.78). Since rs1544410 and rs731236 are in strong linkage disequilibrium, the haplotypes based on these two loci were also tested. The haplotype AC was highly significantly associated with age at surgical menopause (p = 0.008). Women with this haplotype had surgical menopause on average 2.8 years earlier than non-carriers. These results reveal the potential effect of the VDR gene on ovaries and uterus, and suggest that its SNPs can be used as predictors of genetic susceptibility for early surgical menopause and respective causal health problems. © 2006 Informa UK Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/09513590.aspen_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.subject.meshAge Of Onseten_US
dc.subject.meshEuropean Continental Ancestry Group - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHaplotypesen_US
dc.subject.meshHeterozygote Detectionen_US
dc.subject.meshHumansen_US
dc.subject.meshMenopause, Premature - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOvariectomy - Adverse Effectsen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.titlePolymorphisms of the vitamin D receptor gene predict the onset of surgical menopause in Caucasian femalesen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/09513590600988258en_US
dc.identifier.pmid17135034-
dc.identifier.scopuseid_2-s2.0-33845371734en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845371734&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue10en_US
dc.identifier.spage552en_US
dc.identifier.epage556en_US
dc.identifier.isiWOS:000243028300003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridLong, JR=7403446542en_US
dc.identifier.scopusauthoridLiu, PY=7404618030en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridRecker, RR=7007086875en_US
dc.identifier.scopusauthoridDeng, HW=7401775190en_US

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