File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chinese

TitleThe genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chinese
Authors
KeywordsBone mineral content
Bone mineral density
Bone size
Environmental correlation
Genetic correlation
Issue Date2006
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03014460.html
Citation
Annals Of Human Biology, 2006, v. 33 n. 4, p. 500-509 How to Cite?
AbstractBackground: Bone mineral density (BMD), bone mineral content (BMC), and bone size have been widely studied individually as important risk factors for osteoporotic fracture, but little is known about the correlation and the degree of sharing genetic and environmental factors between the pairs of the three phenotypes. Aim: The study investigated genetic correlation (ρG), environmental correlation (ρE) and phenotypic correlation (ρP) between BMD, BMC and bone size. Subjects and methods: Bivariate variance decomposition analyses were performed in 904 subjects from 287 Chinese nuclear families. Results: Significant ρE, ρG and ρP were detected between BMD, BMC and bone size, except for ρE between BMD and bone size at the hip (ρE=0.121, p=0.361). Common shared genetic factors explained 86.1% and 60% of BMD and BMC genetic variations at the spine and hip, respectively. However, the genetic and environmental correlations between BMD and bone size were limited. ρE and ρG at the spine were 0.392 and 0.381, and at the hip were 0.121 and -0.205, respectively. Only 14.5% and 4.2% of variations between BMD and bone size at the spine and hip may be due to the shared genetic factors. Conclusion: The obtained results suggested that bone size may be used as another surrogate phenotype independently of BMD for eventual elucidation of the pathogenesis of osteoporosis because of the limited correlations between BMD and bone size. © 2006 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/178966
ISSN
2015 Impact Factor: 1.57
2015 SCImago Journal Rankings: 0.689
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, YBen_HK
dc.contributor.authorLei, SFen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.contributor.authorSun, Xen_HK
dc.contributor.authorJiang, DKen_HK
dc.contributor.authorLi, MXen_HK
dc.contributor.authorDeng, HWen_HK
dc.date.accessioned2012-12-19T09:51:07Z-
dc.date.available2012-12-19T09:51:07Z-
dc.date.issued2006en_HK
dc.identifier.citationAnnals Of Human Biology, 2006, v. 33 n. 4, p. 500-509en_HK
dc.identifier.issn0301-4460en_HK
dc.identifier.urihttp://hdl.handle.net/10722/178966-
dc.description.abstractBackground: Bone mineral density (BMD), bone mineral content (BMC), and bone size have been widely studied individually as important risk factors for osteoporotic fracture, but little is known about the correlation and the degree of sharing genetic and environmental factors between the pairs of the three phenotypes. Aim: The study investigated genetic correlation (ρG), environmental correlation (ρE) and phenotypic correlation (ρP) between BMD, BMC and bone size. Subjects and methods: Bivariate variance decomposition analyses were performed in 904 subjects from 287 Chinese nuclear families. Results: Significant ρE, ρG and ρP were detected between BMD, BMC and bone size, except for ρE between BMD and bone size at the hip (ρE=0.121, p=0.361). Common shared genetic factors explained 86.1% and 60% of BMD and BMC genetic variations at the spine and hip, respectively. However, the genetic and environmental correlations between BMD and bone size were limited. ρE and ρG at the spine were 0.392 and 0.381, and at the hip were 0.121 and -0.205, respectively. Only 14.5% and 4.2% of variations between BMD and bone size at the spine and hip may be due to the shared genetic factors. Conclusion: The obtained results suggested that bone size may be used as another surrogate phenotype independently of BMD for eventual elucidation of the pathogenesis of osteoporosis because of the limited correlations between BMD and bone size. © 2006 Informa UK Ltd.en_HK
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03014460.htmlen_HK
dc.relation.ispartofAnnals of Human Biologyen_HK
dc.subjectBone mineral contenten_HK
dc.subjectBone mineral densityen_HK
dc.subjectBone sizeen_HK
dc.subjectEnvironmental correlationen_HK
dc.subjectGenetic correlationen_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshBone Density - Physiologyen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshFemaleen_US
dc.subject.meshHip - Anatomy & Histology - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshSpine - Anatomy & Histology - Physiologyen_US
dc.titleThe genetic, environmental and phenotypic correlations of bone phenotypes at the spine and hip in Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.emailLi, MX: mxli@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.identifier.authorityLi, MX=rp01722en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/03014460600814135en_HK
dc.identifier.pmid17060072-
dc.identifier.scopuseid_2-s2.0-33750366463en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750366463&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue4en_HK
dc.identifier.spage500en_HK
dc.identifier.epage509en_HK
dc.identifier.isiWOS:000241100700009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, YB=9038019100en_HK
dc.identifier.scopusauthoridLei, SF=7102453442en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK
dc.identifier.scopusauthoridSun, X=36811239200en_HK
dc.identifier.scopusauthoridJiang, DK=55344960200en_HK
dc.identifier.scopusauthoridLi, MX=17135391100en_HK
dc.identifier.scopusauthoridDeng, HW=34568563000en_HK
dc.identifier.citeulike894717-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats