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Article: Structure and molecular phylogeny of sasA genes in cyanobacteria: Insights into evolution of the prokaryotic circadian system

TitleStructure and molecular phylogeny of sasA genes in cyanobacteria: Insights into evolution of the prokaryotic circadian system
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://mbe.oxfordjournals.org/
Citation
Molecular Biology And Evolution, 2004, v. 21 n. 8, p. 1468-1476 How to Cite?
AbstractCyanobacteria are the simplest organisms known to have a circadian system. In addition to the three well-studied kai genes, kaiA, kaiB, and kaiC, an important element of this system is a two-component sensory transduction histidine kinase sasA. Using publicly available data of complete prokaryotic genomes, we performed structural and phylogenetic analyses of the sasA genes. Results show that this gene has a triple-domain structure, and the domains are under different selective constraints. The sasA gene originated in cyanobacteria probably through the fusion of the ancestral kaiB gene with a double-domain, two-component sensory transduction histidine kinase. The results of the phylogenetic analyses suggest that sasA emerged before the kaiA gene, about 3,000-2,500 MYA, and has evolved in parallel with the evolution of the kaiBC cluster. The observed concordant patterns of the sasA and kaiBC evolution suggest that these genes might compose an ancient KaiBC-SasA-based circadian system, without the kaiA gene, and that such a system still exists in some unicellular cyanobacteria.
Persistent Identifierhttp://hdl.handle.net/10722/178929
ISSN
2015 Impact Factor: 13.649
2015 SCImago Journal Rankings: 8.168
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorDeng, HWen_US
dc.contributor.authorNevo, Een_US
dc.date.accessioned2012-12-19T09:50:48Z-
dc.date.available2012-12-19T09:50:48Z-
dc.date.issued2004en_US
dc.identifier.citationMolecular Biology And Evolution, 2004, v. 21 n. 8, p. 1468-1476en_US
dc.identifier.issn0737-4038en_US
dc.identifier.urihttp://hdl.handle.net/10722/178929-
dc.description.abstractCyanobacteria are the simplest organisms known to have a circadian system. In addition to the three well-studied kai genes, kaiA, kaiB, and kaiC, an important element of this system is a two-component sensory transduction histidine kinase sasA. Using publicly available data of complete prokaryotic genomes, we performed structural and phylogenetic analyses of the sasA genes. Results show that this gene has a triple-domain structure, and the domains are under different selective constraints. The sasA gene originated in cyanobacteria probably through the fusion of the ancestral kaiB gene with a double-domain, two-component sensory transduction histidine kinase. The results of the phylogenetic analyses suggest that sasA emerged before the kaiA gene, about 3,000-2,500 MYA, and has evolved in parallel with the evolution of the kaiBC cluster. The observed concordant patterns of the sasA and kaiBC evolution suggest that these genes might compose an ancient KaiBC-SasA-based circadian system, without the kaiA gene, and that such a system still exists in some unicellular cyanobacteria.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://mbe.oxfordjournals.org/en_US
dc.relation.ispartofMolecular Biology and Evolutionen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBacterial Proteins - Geneticsen_US
dc.subject.meshCircadian Rhythm - Geneticsen_US
dc.subject.meshComputational Biologyen_US
dc.subject.meshCyanobacteria - Geneticsen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshGene Expression Regulation, Bacterial - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhosphotransferases - Geneticsen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshSynechococcus - Geneticsen_US
dc.titleStructure and molecular phylogeny of sasA genes in cyanobacteria: Insights into evolution of the prokaryotic circadian systemen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/molbev/msh106en_US
dc.identifier.pmid15014139-
dc.identifier.scopuseid_2-s2.0-3242785814en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3242785814&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue8en_US
dc.identifier.spage1468en_US
dc.identifier.epage1476en_US
dc.identifier.isiWOS:000222961400002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridDeng, HW=7401775190en_US
dc.identifier.scopusauthoridNevo, E=7102721093en_US

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