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Article: Genetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity

TitleGenetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicity
Authors
KeywordsBody mass index
Bone mineral density
Genetic correlation
Issue Date2006
PublisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198
Citation
Osteoporosis International, 2006, v. 17 n. 1, p. 119-124 How to Cite?
AbstractThe purpose of the present study was to evaluate the magnitude of genetic determination of spine and hip bone mineral density (BMD) and body mass index (BMI), and to explore the genetic, environmental, and phenotypic correlations among the above phenotypes in Chinese Han ethnicity. The sample was composed of at least 217 complete nuclear families in Chinese Han ethnicity. BMD at the spine and hip was measured using a dual-energy X-ray absorptiometry scanner. The heritability (h 2) of BMI and BMD at the spine and hip, the genetic correlation (ρG) and environmental correlation (ρE) among the three phenotypes were evaluated via variance analysis, with age, sex, and age-by-sex interaction as covariates. The phenotypic correlation (ρP) and the bivariate heritability ρG 2 were also calculated. The heritability for BMD and BMI was ∼0.70 and ∼0.50, respectively (p < 0.0001). The common environment shared by household members (household effect) is significant for BMI variation (p = 0.0004). Significant genetic, environmental, and phenotypic correlation was observed. The ρG 2 values were 0.13 for BMI/ spine BMD, 0.18 for BMI/hip BMD, and 0.58 for the spine BMD/hip BMD. While BMD at the spine and hip have significant genetic determination, BMI is more likely to be affected by environmental factors than BMD. In addition, BMD at the spine and hip shares more genetic effect (pleiotropy) than BMI and BMD do in Chinese Han ethnicity, though the effects are significant for both. © International Osteoporosis Foundation and National Osteoporosis Foundation 2005.
Persistent Identifierhttp://hdl.handle.net/10722/178917
ISSN
2015 Impact Factor: 3.445
2015 SCImago Journal Rankings: 1.460
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, FYen_HK
dc.contributor.authorLei, SFen_HK
dc.contributor.authorLi, MXen_HK
dc.contributor.authorJiang, Cen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.contributor.authorDeng, HWen_HK
dc.date.accessioned2012-12-19T09:50:43Z-
dc.date.available2012-12-19T09:50:43Z-
dc.date.issued2006en_HK
dc.identifier.citationOsteoporosis International, 2006, v. 17 n. 1, p. 119-124en_HK
dc.identifier.issn0937-941Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/178917-
dc.description.abstractThe purpose of the present study was to evaluate the magnitude of genetic determination of spine and hip bone mineral density (BMD) and body mass index (BMI), and to explore the genetic, environmental, and phenotypic correlations among the above phenotypes in Chinese Han ethnicity. The sample was composed of at least 217 complete nuclear families in Chinese Han ethnicity. BMD at the spine and hip was measured using a dual-energy X-ray absorptiometry scanner. The heritability (h 2) of BMI and BMD at the spine and hip, the genetic correlation (ρG) and environmental correlation (ρE) among the three phenotypes were evaluated via variance analysis, with age, sex, and age-by-sex interaction as covariates. The phenotypic correlation (ρP) and the bivariate heritability ρG 2 were also calculated. The heritability for BMD and BMI was ∼0.70 and ∼0.50, respectively (p < 0.0001). The common environment shared by household members (household effect) is significant for BMI variation (p = 0.0004). Significant genetic, environmental, and phenotypic correlation was observed. The ρG 2 values were 0.13 for BMI/ spine BMD, 0.18 for BMI/hip BMD, and 0.58 for the spine BMD/hip BMD. While BMD at the spine and hip have significant genetic determination, BMI is more likely to be affected by environmental factors than BMD. In addition, BMD at the spine and hip shares more genetic effect (pleiotropy) than BMI and BMD do in Chinese Han ethnicity, though the effects are significant for both. © International Osteoporosis Foundation and National Osteoporosis Foundation 2005.en_HK
dc.languageengen_US
dc.publisherSpringer U K. The Journal's web site is located at http://www.springer.com/medicine/orthopedics/journal/198en_HK
dc.relation.ispartofOsteoporosis Internationalen_HK
dc.subjectBody mass indexen_HK
dc.subjectBone mineral densityen_HK
dc.subjectGenetic correlationen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBody Height - Physiologyen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshBody Weight - Physiologyen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHip Joint - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLumbar Vertebrae - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshObesity - Etiology - Genetics - Physiopathologyen_US
dc.subject.meshOsteoporosis - Etiology - Genetics - Physiopathologyen_US
dc.subject.meshPhenotypeen_US
dc.titleGenetic determination and correlation of body mass index and bone mineral density at the spine and hip in Chinese Han ethnicityen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, MX: mxli@hku.hken_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityLi, MX=rp01722en_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00198-005-1930-4en_HK
dc.identifier.pmid16025191-
dc.identifier.scopuseid_2-s2.0-29144532082en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29144532082&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue1en_HK
dc.identifier.spage119en_HK
dc.identifier.epage124en_HK
dc.identifier.isiWOS:000233997900016-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridDeng, FY=19640145800en_HK
dc.identifier.scopusauthoridLei, SF=7102453442en_HK
dc.identifier.scopusauthoridLi, MX=17135391100en_HK
dc.identifier.scopusauthoridJiang, C=36484765000en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK
dc.identifier.scopusauthoridDeng, HW=34568563000en_HK

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