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Article: Functional divergence of the circadian clock proteins in prokaryotes

TitleFunctional divergence of the circadian clock proteins in prokaryotes
Authors
Issue Date2005
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0016-6707
Citation
Genetica, 2005, v. 124 n. 2, p. 247-254 How to Cite?
AbstractCyanobacteria are only prokaryotes known so far to have a circadian system. It may be based either on two (kaiB and kaiC) or three (kaiA, kaiB and kaiC) circadian genes. The homologs of two circadian proteins, KaiB and KaiC, form four major subfamilies (K1-K4) and also occur in some other prokaryotes. Using the likelihood-ratio tests, we studied a rate shift at the functional divergence of the proteins from the different subfamilies. It appears that only two of the subfamilies (K1 and K2) perform circadian functions. We identified in total 92 sites that have significantly different rates of evolution between the clades K1/K2 and K3/K4; 67 sites (15 in KaiB and 52 in KaiC) been evolving significantly slower in K1/K2 than the overall average for the entire sequence. Many critical sites are located in the identified functionally important motifs and regions, e.g. one of the Walker's motif As, DXXG motif, and two KaiA-binding domains of KaiC. There are also 36 sites (∼5%) with rate shift between K1 and K2. The rate shift at these sites may be related to the interaction with KaiA. Rate shift analyses have identified residues whose manipulation in the Kai proteins may lead to better understanding of their functions in the two different types of the cyanobacterial circadian system. © Springer 2005.
Persistent Identifierhttp://hdl.handle.net/10722/178892
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.616
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorKnudsen, Ben_US
dc.date.accessioned2012-12-19T09:50:30Z-
dc.date.available2012-12-19T09:50:30Z-
dc.date.issued2005en_US
dc.identifier.citationGenetica, 2005, v. 124 n. 2, p. 247-254en_US
dc.identifier.issn0016-6707en_US
dc.identifier.urihttp://hdl.handle.net/10722/178892-
dc.description.abstractCyanobacteria are only prokaryotes known so far to have a circadian system. It may be based either on two (kaiB and kaiC) or three (kaiA, kaiB and kaiC) circadian genes. The homologs of two circadian proteins, KaiB and KaiC, form four major subfamilies (K1-K4) and also occur in some other prokaryotes. Using the likelihood-ratio tests, we studied a rate shift at the functional divergence of the proteins from the different subfamilies. It appears that only two of the subfamilies (K1 and K2) perform circadian functions. We identified in total 92 sites that have significantly different rates of evolution between the clades K1/K2 and K3/K4; 67 sites (15 in KaiB and 52 in KaiC) been evolving significantly slower in K1/K2 than the overall average for the entire sequence. Many critical sites are located in the identified functionally important motifs and regions, e.g. one of the Walker's motif As, DXXG motif, and two KaiA-binding domains of KaiC. There are also 36 sites (∼5%) with rate shift between K1 and K2. The rate shift at these sites may be related to the interaction with KaiA. Rate shift analyses have identified residues whose manipulation in the Kai proteins may lead to better understanding of their functions in the two different types of the cyanobacterial circadian system. © Springer 2005.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0016-6707en_US
dc.relation.ispartofGeneticaen_US
dc.subject.meshAmino Acid Motifsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBacterial Proteins - Chemistry - Genetics - Physiologyen_US
dc.subject.meshCircadian Rhythm - Genetics - Physiologyen_US
dc.subject.meshCircadian Rhythm Signaling Peptides And Proteinsen_US
dc.subject.meshCyanobacteria - Genetics - Physiologyen_US
dc.subject.meshEvolution, Molecularen_US
dc.subject.meshGenes, Bacterialen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshProkaryotic Cellsen_US
dc.subject.meshProtein Structure, Tertiaryen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titleFunctional divergence of the circadian clock proteins in prokaryotesen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10709-005-3146-0en_US
dc.identifier.pmid16134337-
dc.identifier.scopuseid_2-s2.0-21744462237en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21744462237&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume124en_US
dc.identifier.issue2en_US
dc.identifier.spage247en_US
dc.identifier.epage254en_US
dc.identifier.isiWOS:000230266000013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridKnudsen, B=7004937723en_US
dc.identifier.citeulike246378-

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