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Article: Rheological properties of erythrocytes from male hypercholesterolemia

TitleRheological properties of erythrocytes from male hypercholesterolemia
Authors
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvre
Citation
Microvascular Research, 2004, v. 67 n. 2, p. 133-138 How to Cite?
AbstractDiet and general health status has close relation to the flow behavior of blood, which influences the circulation of the blood in the body. In this study, we have compared the rheological properties of erythrocyte, plasma and whole blood from high-cholesterol male subjects with healthy male subjects. Intravenous blood was taken from healthy males (n = 10) and males with high cholesterol (n = 14). Basic health profile, BMI, hematological count and lipid profile (total cholesterol, LDL, HDL and triglyceride) of the blood were determined. Viscosity and shear rate dependent flow behavior of the subjects blood were measured by cone and plate rheometer, and permeability of erythrocytes by pulsed field gradient NMR. Using the microchannel flow analyzer (MC-FAN), the microcirculation of erythrocyte and plasma were investigated. Our data showed a difference in viscosity and consistency index of the whole blood, and permeability (P < 0.05) of erythrocytes between the two groups. Also, the time taken for the flow of erythrocyte and plasma through the MC-FAN was slower for the high-cholesterol group. Correlation study showed that consistency index of the blood is closely related to the level of LDL (P < 0.05), and total cholesterol, HDL and LDL (P < 0.01) highly correlated with the microcirculation of erythrocyte and plasma. A negative correlation (P < 0.05) was found between total cholesterol, HDL and LDL, and permeability of erythrocytes. It is concluded that high level of cholesterol, LDL and HDL in vivo alter the morphology and flow behavior of blood cells that can subsequently increase the risk of impairing physical function and microcirculation. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/178864
ISSN
2015 Impact Factor: 2.3
2015 SCImago Journal Rankings: 1.030
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, CYJen_US
dc.contributor.authorKim, KCen_US
dc.contributor.authorPark, HWen_US
dc.contributor.authorSong, JHen_US
dc.contributor.authorLee, CHen_US
dc.date.accessioned2012-12-19T09:50:15Z-
dc.date.available2012-12-19T09:50:15Z-
dc.date.issued2004en_US
dc.identifier.citationMicrovascular Research, 2004, v. 67 n. 2, p. 133-138en_US
dc.identifier.issn0026-2862en_US
dc.identifier.urihttp://hdl.handle.net/10722/178864-
dc.description.abstractDiet and general health status has close relation to the flow behavior of blood, which influences the circulation of the blood in the body. In this study, we have compared the rheological properties of erythrocyte, plasma and whole blood from high-cholesterol male subjects with healthy male subjects. Intravenous blood was taken from healthy males (n = 10) and males with high cholesterol (n = 14). Basic health profile, BMI, hematological count and lipid profile (total cholesterol, LDL, HDL and triglyceride) of the blood were determined. Viscosity and shear rate dependent flow behavior of the subjects blood were measured by cone and plate rheometer, and permeability of erythrocytes by pulsed field gradient NMR. Using the microchannel flow analyzer (MC-FAN), the microcirculation of erythrocyte and plasma were investigated. Our data showed a difference in viscosity and consistency index of the whole blood, and permeability (P < 0.05) of erythrocytes between the two groups. Also, the time taken for the flow of erythrocyte and plasma through the MC-FAN was slower for the high-cholesterol group. Correlation study showed that consistency index of the blood is closely related to the level of LDL (P < 0.05), and total cholesterol, HDL and LDL (P < 0.01) highly correlated with the microcirculation of erythrocyte and plasma. A negative correlation (P < 0.05) was found between total cholesterol, HDL and LDL, and permeability of erythrocytes. It is concluded that high level of cholesterol, LDL and HDL in vivo alter the morphology and flow behavior of blood cells that can subsequently increase the risk of impairing physical function and microcirculation. © 2004 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvreen_US
dc.relation.ispartofMicrovascular Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshBasal Metabolismen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshBlood Viscosityen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshErythrocyte Indicesen_US
dc.subject.meshHemorheologyen_US
dc.subject.meshHumansen_US
dc.subject.meshHypercholesterolemia - Blooden_US
dc.subject.meshLipids - Blooden_US
dc.subject.meshLipoproteins, Ldl - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculationen_US
dc.subject.meshNuclear Magnetic Resonance, Biomolecularen_US
dc.subject.meshPlasmaen_US
dc.titleRheological properties of erythrocytes from male hypercholesterolemiaen_US
dc.typeArticleen_US
dc.identifier.emailLee, CYJ: jettylee@hku.hken_US
dc.identifier.authorityLee, CYJ=rp01511en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.mvr.2003.12.006en_US
dc.identifier.pmid15020204-
dc.identifier.scopuseid_2-s2.0-1542358729en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542358729&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume67en_US
dc.identifier.issue2en_US
dc.identifier.spage133en_US
dc.identifier.epage138en_US
dc.identifier.isiWOS:000220292900004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLee, CYJ=13104265200en_US
dc.identifier.scopusauthoridKim, KC=35092706000en_US
dc.identifier.scopusauthoridPark, HW=7601569817en_US
dc.identifier.scopusauthoridSong, JH=7404788259en_US
dc.identifier.scopusauthoridLee, CH=7410151030en_US

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