File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese

TitleInteraction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese
Authors
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.html
Citation
Journal Of Human Genetics, 2003, v. 48 n. 10, p. 514-519 How to Cite?
AbstractWe evaluated the interaction effects between the estrogen receptor α gene (ER-α), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-α gene and ApaI in the VDR gene were detected by RFLP, and ER-α genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction (P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD (P < 0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample.
Persistent Identifierhttp://hdl.handle.net/10722/178832
ISSN
2015 Impact Factor: 2.487
2015 SCImago Journal Rankings: 1.416
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLong, Jen_US
dc.contributor.authorLiu, Pen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorDvornyk, Ven_US
dc.contributor.authorDeng, HWen_US
dc.date.accessioned2012-12-19T09:50:01Z-
dc.date.available2012-12-19T09:50:01Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Human Genetics, 2003, v. 48 n. 10, p. 514-519en_US
dc.identifier.issn1434-5161en_US
dc.identifier.urihttp://hdl.handle.net/10722/178832-
dc.description.abstractWe evaluated the interaction effects between the estrogen receptor α gene (ER-α), vitamin D receptor gene (VDR), age and sex on bone mineral density (BMD) in a sample of 340 unrelated males and 297 unrelated females from 401 Chinese nuclear families. Polymorphisms of PvuII and XbaI in the ER-α gene and ApaI in the VDR gene were detected by RFLP, and ER-α genotype was defined by the haplotype reconstructed according to the two loci. In the females, significant ER-VDR gene interaction (P<0.05) was found on the lumbar spine BMD. Such interaction might account for approximately 1.0% of the BMD variation. At the femoral neck and trochanter, significant ER-age interaction effects were observed, which might explain 0.3% BMD variation for both skeletal sites. In the males, significant VDR-age interaction was found on femoral neck BMD (P < 0.05), and it accounted for 0.6% BMD variation. These interaction effects were largely dependent on gender groups, suggesting there may exist ER-VDR-sex, ER-age-sex, and VDR-age-sex complex interactions in our Chinese sample.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhg/index.htmlen_US
dc.relation.ispartofJournal of Human Geneticsen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshEstrogen Receptor Alphaen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshReceptors, Calcitriol - Geneticsen_US
dc.subject.meshReceptors, Estrogen - Geneticsen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSex Factorsen_US
dc.titleInteraction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_US
dc.identifier.authorityDvornyk, V=rp00693en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10038-003-0068-5en_US
dc.identifier.pmid14505233-
dc.identifier.scopuseid_2-s2.0-0344873312en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0344873312&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume48en_US
dc.identifier.issue10en_US
dc.identifier.spage514en_US
dc.identifier.epage519en_US
dc.identifier.isiWOS:000186242800004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLong, J=7403446542en_US
dc.identifier.scopusauthoridLiu, P=7404618030en_US
dc.identifier.scopusauthoridZhang, Y=12781205700en_US
dc.identifier.scopusauthoridShen, H=36126870600en_US
dc.identifier.scopusauthoridLiu, Y=36065513000en_US
dc.identifier.scopusauthoridDvornyk, V=6701789786en_US
dc.identifier.scopusauthoridDeng, HW=34568563000en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats