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Article: Ovarian surface epithelium: Biology, endocrinology, and pathology

TitleOvarian surface epithelium: Biology, endocrinology, and pathology
Authors
Issue Date2001
PublisherThe Endocrine Society. The Journal's web site is located at http://edrv.endojournals.org
Citation
Endocrine Reviews, 2001, v. 22 n. 2, p. 255-288 How to Cite?
AbstractThe epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The objective of this article is to review the cellular and molecular mechanisms that underlie the control of normal and neoplastic OSE cell growth, differentiation, and expression of indicators of neoplastic progression. We begin with a brief discussion of the development of OSE, from embryonic to the adult. The pathological and genetic changes of OSE during neoplastic progression are next summarized. The histological characteristics of OSE cells in culture are also described. Finally, the potential involvement of hormones, growth factors, and cytokines is discussed in terms of their contribution to our understanding of the physiology of normal OSE and ovarian cancer development.
Persistent Identifierhttp://hdl.handle.net/10722/178741
ISSN
2015 Impact Factor: 14.898
2015 SCImago Journal Rankings: 7.086
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAuersperg, Nen_US
dc.contributor.authorWong, ASTen_US
dc.contributor.authorChoi, KCen_US
dc.contributor.authorKang, SKen_US
dc.contributor.authorLeung, PCKen_US
dc.date.accessioned2012-12-19T09:49:26Z-
dc.date.available2012-12-19T09:49:26Z-
dc.date.issued2001en_US
dc.identifier.citationEndocrine Reviews, 2001, v. 22 n. 2, p. 255-288en_US
dc.identifier.issn0163-769Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/178741-
dc.description.abstractThe epithelial ovarian carcinomas, which make up more than 85% of human ovarian cancer, arise in the ovarian surface epithelium (OSE). The etiology and early events in the progression of these carcinomas are among the least understood of all major human malignancies because there are no appropriate animal models, and because methods to culture OSE have become available only recently. The objective of this article is to review the cellular and molecular mechanisms that underlie the control of normal and neoplastic OSE cell growth, differentiation, and expression of indicators of neoplastic progression. We begin with a brief discussion of the development of OSE, from embryonic to the adult. The pathological and genetic changes of OSE during neoplastic progression are next summarized. The histological characteristics of OSE cells in culture are also described. Finally, the potential involvement of hormones, growth factors, and cytokines is discussed in terms of their contribution to our understanding of the physiology of normal OSE and ovarian cancer development.en_US
dc.languageengen_US
dc.publisherThe Endocrine Society. The Journal's web site is located at http://edrv.endojournals.orgen_US
dc.relation.ispartofEndocrine Reviewsen_US
dc.subject.meshAdulten_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshEpithelium - Pathology - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshOvarian Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshOvary - Pathology - Physiologyen_US
dc.titleOvarian surface epithelium: Biology, endocrinology, and pathologyen_US
dc.typeArticleen_US
dc.identifier.emailWong, AST: awong1@hkucc.hku.hken_US
dc.identifier.authorityWong, AST=rp00805en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1210/er.22.2.255en_US
dc.identifier.pmid11294827-
dc.identifier.scopuseid_2-s2.0-0035008525en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035008525&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.spage255en_US
dc.identifier.epage288en_US
dc.identifier.isiWOS:000168099300006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAuersperg, N=7006582556en_US
dc.identifier.scopusauthoridWong, AST=23987963300en_US
dc.identifier.scopusauthoridChoi, KC=7403949681en_US
dc.identifier.scopusauthoridKang, SK=25623598700en_US
dc.identifier.scopusauthoridLeung, PCK=55419381000en_US
dc.identifier.citeulike6536132-

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