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Article: High glucose concentrations induce oxidative damage to mitochondrial DNA in explanted vascular smooth muscle cells

TitleHigh glucose concentrations induce oxidative damage to mitochondrial DNA in explanted vascular smooth muscle cells
Authors
Issue Date2001
PublisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/
Citation
Experimental Biology And Medicine, 2001, v. 226 n. 5, p. 450-457 How to Cite?
AbstractOxidative stress is considered to be one of the mechanisms leading to atherosclerosis. It occurs in response to injury or to altered metabolic state. Alterations in cell growth (proliferation or apoptosis) can also contribute to the pathogenesis of atherosclerosis and is influenced by oxidative stress. Smooth muscle cells (SMC) from aortic explants of JCR:LA-cp homozygous cp/cp corpulent rats who are genetically predisposed to develop atherosclerosis exhibit increased SMC proliferation, which can be attenuated by exercise and food restriction. This study was conducted to characterize the effects fo oxidative stress and high glucose media on cell growth and its relationship to mitochondrial DNA integrity and gene expression in explanted aortic SMC from corpulent and lean JCR:LA-cp rats. The results show that SMC from the cp/cp rat appear to be resistant to oxidant-induced cell death and that they accumulate mitochondrial DNA mutations, probably as a result of a reduction in apoptosis. These data suggest that susceptibility to age-and glucose-related atherosclerosis may be related to alterations in redox signaling.
Persistent Identifierhttp://hdl.handle.net/10722/178736
ISSN
2002 Impact Factor: 2.714
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, SCYen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorLeung, FCen_US
dc.date.accessioned2012-12-19T09:49:24Z-
dc.date.available2012-12-19T09:49:24Z-
dc.date.issued2001en_US
dc.identifier.citationExperimental Biology And Medicine, 2001, v. 226 n. 5, p. 450-457en_US
dc.identifier.issn0037-9727en_US
dc.identifier.urihttp://hdl.handle.net/10722/178736-
dc.description.abstractOxidative stress is considered to be one of the mechanisms leading to atherosclerosis. It occurs in response to injury or to altered metabolic state. Alterations in cell growth (proliferation or apoptosis) can also contribute to the pathogenesis of atherosclerosis and is influenced by oxidative stress. Smooth muscle cells (SMC) from aortic explants of JCR:LA-cp homozygous cp/cp corpulent rats who are genetically predisposed to develop atherosclerosis exhibit increased SMC proliferation, which can be attenuated by exercise and food restriction. This study was conducted to characterize the effects fo oxidative stress and high glucose media on cell growth and its relationship to mitochondrial DNA integrity and gene expression in explanted aortic SMC from corpulent and lean JCR:LA-cp rats. The results show that SMC from the cp/cp rat appear to be resistant to oxidant-induced cell death and that they accumulate mitochondrial DNA mutations, probably as a result of a reduction in apoptosis. These data suggest that susceptibility to age-and glucose-related atherosclerosis may be related to alterations in redox signaling.en_US
dc.languageengen_US
dc.publisherSociety for Experimental Biology and Medicine. The Journal's web site is located at http://www.ebmonline.org/en_US
dc.relation.ispartofExperimental Biology and Medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshArteriosclerosis - Etiology - Genetics - Metabolismen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCatalase - Pharmacologyen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshDna Damageen_US
dc.subject.meshDna Primers - Geneticsen_US
dc.subject.meshDna, Mitochondrial - Drug Effects - Genetics - Metabolismen_US
dc.subject.meshGene Expression - Drug Effectsen_US
dc.subject.meshGlucose - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMuscle, Smooth, Vascular - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Mutant Strainsen_US
dc.subject.meshSuperoxide Dismutase - Pharmacologyen_US
dc.titleHigh glucose concentrations induce oxidative damage to mitochondrial DNA in explanted vascular smooth muscle cellsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, FC: fcleung@hkucc.hku.hken_US
dc.identifier.authorityLeung, FC=rp00731en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11393174-
dc.identifier.scopuseid_2-s2.0-0034982616en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034982616&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume226en_US
dc.identifier.issue5en_US
dc.identifier.spage450en_US
dc.identifier.epage457en_US
dc.identifier.isiWOS:000168542500010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridIp, SCY=36940461900en_US
dc.identifier.scopusauthoridZhang, X=8439058600en_US
dc.identifier.scopusauthoridLeung, FC=7103078633en_US

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