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Article: Metallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide

TitleMetallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxide
Authors
Issue Date2001
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphere
Citation
Chemosphere, 2001, v. 44 n. 3, p. 321-325 How to Cite?
AbstractIt has been suggested that metallothionein (MT) not only can regulate essential metals and detoxify toxic metals, but that MT can also play a significant role as an antioxidant and can be induced by oxidative stresses other than metals. This study is aimed at investigating the effect of hydrogen peroxide (H2O2), and the combined effect of H2O2 and cadmium (Cd) on MT induction and condition index (CI) in dogwhelks Nucella lapillus. Adult male dogwhelks (27 ± 1 mm in shell length) were exposed for 20 days to (1) control (filtered natural seawater only); (2), 0.50 ppm Cd; (3) 2.0 ppm H2O2 + 0.50 ppm Cd; (4) 1.0 ppm H2O2 + 0.25 ppm Cd; (5) 2.0 ppm H2O2; (6) 1000 ppm H2O2 or (7) 1000 ppm H2O2 + 0.50 ppm Cd. The concentration of MT in the Leiblein gland of N. lapillus was quantified using the silver saturation method. MT or MT-like proteins in the animals were induced by Cd (0.5 ppm), H2O2 (2.0 ppm) or Cd + H2O2, indicating that MT in this gastropod species can be induced by either metal or oxidative stresses. Exposure to high H2O2 (1000 ppm) alone or combined with Cd, and exposure to Cd (0.50 ppm) or H2O2 (2.0 ppm), resulted in significant weight loss, indicated by a reduction of CI. However, CIs of groups (3) and (4) were similar to that of the control suggesting that Cd antagonistically reduces toxicity caused by H2O2 since Cd-induced MT may have a protective function against hydroxyl radicals. © 2001 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/178732
ISSN
2015 Impact Factor: 3.698
2015 SCImago Journal Rankings: 1.536
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, KMYen_US
dc.contributor.authorFurness, RWen_US
dc.date.accessioned2012-12-19T09:49:22Z-
dc.date.available2012-12-19T09:49:22Z-
dc.date.issued2001en_US
dc.identifier.citationChemosphere, 2001, v. 44 n. 3, p. 321-325en_US
dc.identifier.issn0045-6535en_US
dc.identifier.urihttp://hdl.handle.net/10722/178732-
dc.description.abstractIt has been suggested that metallothionein (MT) not only can regulate essential metals and detoxify toxic metals, but that MT can also play a significant role as an antioxidant and can be induced by oxidative stresses other than metals. This study is aimed at investigating the effect of hydrogen peroxide (H2O2), and the combined effect of H2O2 and cadmium (Cd) on MT induction and condition index (CI) in dogwhelks Nucella lapillus. Adult male dogwhelks (27 ± 1 mm in shell length) were exposed for 20 days to (1) control (filtered natural seawater only); (2), 0.50 ppm Cd; (3) 2.0 ppm H2O2 + 0.50 ppm Cd; (4) 1.0 ppm H2O2 + 0.25 ppm Cd; (5) 2.0 ppm H2O2; (6) 1000 ppm H2O2 or (7) 1000 ppm H2O2 + 0.50 ppm Cd. The concentration of MT in the Leiblein gland of N. lapillus was quantified using the silver saturation method. MT or MT-like proteins in the animals were induced by Cd (0.5 ppm), H2O2 (2.0 ppm) or Cd + H2O2, indicating that MT in this gastropod species can be induced by either metal or oxidative stresses. Exposure to high H2O2 (1000 ppm) alone or combined with Cd, and exposure to Cd (0.50 ppm) or H2O2 (2.0 ppm), resulted in significant weight loss, indicated by a reduction of CI. However, CIs of groups (3) and (4) were similar to that of the control suggesting that Cd antagonistically reduces toxicity caused by H2O2 since Cd-induced MT may have a protective function against hydroxyl radicals. © 2001 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/chemosphereen_US
dc.relation.ispartofChemosphereen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiological Markers - Analysisen_US
dc.subject.meshCadmium - Adverse Effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshHydrogen Peroxide - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMetallothionein - Chemical Synthesisen_US
dc.subject.meshMollusca - Physiologyen_US
dc.subject.meshOxidants - Pharmacologyen_US
dc.subject.meshOxidation-Reductionen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshWater Pollutants - Adverse Effectsen_US
dc.titleMetallothionein induction and condition index of dogwhelks Nucella lapillus (L.) exposed to cadmium and hydrogen peroxideen_US
dc.typeArticleen_US
dc.identifier.emailLeung, KMY: kmyleung@hku.hken_US
dc.identifier.authorityLeung, KMY=rp00733en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0045-6535(00)00297-6en_US
dc.identifier.pmid11459135-
dc.identifier.scopuseid_2-s2.0-0034963408en_US
dc.identifier.hkuros65778-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034963408&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue3en_US
dc.identifier.spage321en_US
dc.identifier.epage325en_US
dc.identifier.isiWOS:000169652100002-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLeung, KMY=7401860738en_US
dc.identifier.scopusauthoridFurness, RW=7103164978en_US

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