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Article: A perfusion-cell bleeding culture strategy for enhancing the productivity of eicosapentaenoic acid by Nitzschia laevis

TitleA perfusion-cell bleeding culture strategy for enhancing the productivity of eicosapentaenoic acid by Nitzschia laevis
Authors
Issue Date2001
PublisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00253/index.htm
Citation
Applied Microbiology And Biotechnology, 2001, v. 57 n. 3, p. 316-322 How to Cite?
AbstractA perfusion-cell bleeding culture strategy was developed for enhancing the productivity of eicosapentaenoic acid (EPA) by the diatom Nitzschia laevis. As the strategy combined the concepts of continuous culture and perfusion culture, it allowed continuously and simultaneously harvesting the algal cells and removing inhibitory compounds during the cultivation. Compared with a single operation of continuous culture, the perfusion-cell bleeding culture greatly enhanced the steady-state biomass concentration, biomass productivity, EPA yield, EPA productivity and glucose utilization efficiency. The perfusion-cell bleeding culture also allowed higher biomass productivity and EPA productivity than the single perfusion culture did. At a bleeding rate of 0.67 day-1 and a perfusion rate of 0.6 day-1, the EPA productivity achieved 175 mg 1-1 day-1, which is the highest ever reported in microalgal cultures.
Persistent Identifierhttp://hdl.handle.net/10722/178725
ISSN
2015 Impact Factor: 3.376
2015 SCImago Journal Rankings: 1.262
References

 

DC FieldValueLanguage
dc.contributor.authorWen, ZYen_US
dc.contributor.authorChen, Fen_US
dc.date.accessioned2012-12-19T09:49:21Z-
dc.date.available2012-12-19T09:49:21Z-
dc.date.issued2001en_US
dc.identifier.citationApplied Microbiology And Biotechnology, 2001, v. 57 n. 3, p. 316-322en_US
dc.identifier.issn0175-7598en_US
dc.identifier.urihttp://hdl.handle.net/10722/178725-
dc.description.abstractA perfusion-cell bleeding culture strategy was developed for enhancing the productivity of eicosapentaenoic acid (EPA) by the diatom Nitzschia laevis. As the strategy combined the concepts of continuous culture and perfusion culture, it allowed continuously and simultaneously harvesting the algal cells and removing inhibitory compounds during the cultivation. Compared with a single operation of continuous culture, the perfusion-cell bleeding culture greatly enhanced the steady-state biomass concentration, biomass productivity, EPA yield, EPA productivity and glucose utilization efficiency. The perfusion-cell bleeding culture also allowed higher biomass productivity and EPA productivity than the single perfusion culture did. At a bleeding rate of 0.67 day-1 and a perfusion rate of 0.6 day-1, the EPA productivity achieved 175 mg 1-1 day-1, which is the highest ever reported in microalgal cultures.en_US
dc.languageengen_US
dc.publisherSpringer. The Journal's web site is located at http://link.springer.de/link/service/journals/00253/index.htmen_US
dc.relation.ispartofApplied Microbiology and Biotechnologyen_US
dc.subject.meshBiomassen_US
dc.subject.meshBioreactorsen_US
dc.subject.meshDiatoms - Growth & Development - Metabolismen_US
dc.subject.meshEicosapentaenoic Acid - Analysis - Biosynthesisen_US
dc.titleA perfusion-cell bleeding culture strategy for enhancing the productivity of eicosapentaenoic acid by Nitzschia laevisen_US
dc.typeArticleen_US
dc.identifier.emailChen, F: sfchen@hku.hken_US
dc.identifier.authorityChen, F=rp00672en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s002530100786en_US
dc.identifier.pmid11759678-
dc.identifier.scopuseid_2-s2.0-0034793636en_US
dc.identifier.hkuros72409-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034793636&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume57en_US
dc.identifier.issue3en_US
dc.identifier.spage316en_US
dc.identifier.epage322en_US
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridWen, ZY=14012373200en_US
dc.identifier.scopusauthoridChen, F=7404907980en_US

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