File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Relationship between ultrastructural changes and EROD activities in liver of fish exposed to Benzo[a]pyrene

TitleRelationship between ultrastructural changes and EROD activities in liver of fish exposed to Benzo[a]pyrene
Authors
KeywordsBiomarkers
Erod Activity
Hepatic Morphometry
Lipofuscin Granule
Pahs
Issue Date1999
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/envpol
Citation
Environmental Pollution, 1999, v. 104 n. 2, p. 235-247 How to Cite?
AbstractLaboratory experiments were carried out to investigate the relationship between hepatocytological changes and EROD activities in the demersal fish Solea ovata up to 7 days following intraperitoneal injection of 0.1, 0.5, 1, 5 and 10 mg/kg benzo[a]pyrene (B[a]P). At 1 and 5 mg/kg of B[a]P, observable cytological alterations involved increase in abundance of lipofuscin granules, peroxisomes, mitochondria, lipid droplets and lysosomes, slight proliferation of the ER system, and glycogen depletion. At a higher dose (10 mg/kg) of B[a]P, condensation of cytoplasmic content was observed. Stereological analysis also showed apparent changes in hepatic lipofuscin granules, peroxisomes, mitochondria and lipids in response to B[a]P exposure. Experimental results demonstrated a good dose-response relationship between exposure to B[a]P and changes in EROD activities. Numerical densities of hepatic lipofuscin granules and peroxisomes were significantly correlated with EROD activities (r=0.84, 0.75, respectively, P<0.01). The possible relationship between EROD induction, increases of lipofuscin granules and peroxisomes as a result of B[a]P exposure in S. ovata is discussed. The observed link between EROD induction and hepatocytological changes in response to toxicant exposure provides a more meaningful interpretation of EROD induction in ecotoxicological studies. Copyright (C) 1998 Elsevier Science Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/178671
ISSN
2015 Impact Factor: 4.839
2015 SCImago Journal Rankings: 2.045
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, DWTen_US
dc.contributor.authorWu, RSSen_US
dc.contributor.authorZhou, BSen_US
dc.contributor.authorLam, PKSen_US
dc.date.accessioned2012-12-19T09:49:03Z-
dc.date.available2012-12-19T09:49:03Z-
dc.date.issued1999en_US
dc.identifier.citationEnvironmental Pollution, 1999, v. 104 n. 2, p. 235-247en_US
dc.identifier.issn0269-7491en_US
dc.identifier.urihttp://hdl.handle.net/10722/178671-
dc.description.abstractLaboratory experiments were carried out to investigate the relationship between hepatocytological changes and EROD activities in the demersal fish Solea ovata up to 7 days following intraperitoneal injection of 0.1, 0.5, 1, 5 and 10 mg/kg benzo[a]pyrene (B[a]P). At 1 and 5 mg/kg of B[a]P, observable cytological alterations involved increase in abundance of lipofuscin granules, peroxisomes, mitochondria, lipid droplets and lysosomes, slight proliferation of the ER system, and glycogen depletion. At a higher dose (10 mg/kg) of B[a]P, condensation of cytoplasmic content was observed. Stereological analysis also showed apparent changes in hepatic lipofuscin granules, peroxisomes, mitochondria and lipids in response to B[a]P exposure. Experimental results demonstrated a good dose-response relationship between exposure to B[a]P and changes in EROD activities. Numerical densities of hepatic lipofuscin granules and peroxisomes were significantly correlated with EROD activities (r=0.84, 0.75, respectively, P<0.01). The possible relationship between EROD induction, increases of lipofuscin granules and peroxisomes as a result of B[a]P exposure in S. ovata is discussed. The observed link between EROD induction and hepatocytological changes in response to toxicant exposure provides a more meaningful interpretation of EROD induction in ecotoxicological studies. Copyright (C) 1998 Elsevier Science Ltd.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/envpolen_US
dc.relation.ispartofEnvironmental Pollutionen_US
dc.subjectBiomarkersen_US
dc.subjectErod Activityen_US
dc.subjectHepatic Morphometryen_US
dc.subjectLipofuscin Granuleen_US
dc.subjectPahsen_US
dc.titleRelationship between ultrastructural changes and EROD activities in liver of fish exposed to Benzo[a]pyreneen_US
dc.typeArticleen_US
dc.identifier.emailWu, RSS: rudolfwu@hku.hken_US
dc.identifier.authorityWu, RSS=rp01398en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0269-7491(98)00176-6en_US
dc.identifier.scopuseid_2-s2.0-0033005012en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033005012&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue2en_US
dc.identifier.spage235en_US
dc.identifier.epage247en_US
dc.identifier.isiWOS:000078178500008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, DWT=7004909228en_US
dc.identifier.scopusauthoridWu, RSS=7402945079en_US
dc.identifier.scopusauthoridZhou, BS=7401906781en_US
dc.identifier.scopusauthoridLam, PKS=7202365776en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats