File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Characterization of the murine gene of gClqBP, a novel cell protein that binds the globular heads of Clq, vitronectin, high molecular weight kininogen and factor XII

TitleCharacterization of the murine gene of gClqBP, a novel cell protein that binds the globular heads of Clq, vitronectin, high molecular weight kininogen and factor XII
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gene
Citation
Gene, 1998, v. 209 n. 1-2, p. 229-237 How to Cite?
AbstractgClqBP is a novel cell protein which was found to interact with the globular heads of Clq, high mol. wt kininogen, factor XII and the heparin-binding, multimeric form of vitronectin. The protein sequence shows no homology to any protein family. This paper describes the genomic organization of mouse gClqBP and the characterization of its 5' flanking region. The mouse gene consists of six exons separated by five introns, and its total length is approximately 6 kb. Exon 1 encodes the putative signal peptide, a long stretch of 70 amino acid residues, and the first four amino acid residues found in the mature gClqBP. Exons 2-5 encode four very hydrophilic domains, whereas exon 6 encodes a neutral domain. The amino acid sequence responsible for binding to the heparin-binding, multimeric form of vitronectin is located in exon 2. A 1 kb DNA fragment upstream of the first initiation codon was sequenced, which contained four potential TATA boxes, seven CAAT boxes, six SP1 sites and various putative transcription factor-binding elements, indicating that the promoter region is in close proximity to the first exon. The mouse Clqbp gene was mapped to chromosome 11, closely linked to D11Mit4 using genomic DNAs from a (C57BL/6J x Mus spretus)F1 x Mus spretus backcross.
Persistent Identifierhttp://hdl.handle.net/10722/178643
ISSN
2015 Impact Factor: 2.319
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, BLen_US
dc.contributor.authorWhite, RAen_US
dc.contributor.authorHummel, GSen_US
dc.contributor.authorSchwaeble, Wen_US
dc.contributor.authorMak, SCen_US
dc.contributor.authorPeerschke, EIBen_US
dc.contributor.authorReid, KBMen_US
dc.contributor.authorGhebrehiwet, Ben_US
dc.date.accessioned2012-12-19T09:48:54Z-
dc.date.available2012-12-19T09:48:54Z-
dc.date.issued1998en_US
dc.identifier.citationGene, 1998, v. 209 n. 1-2, p. 229-237en_US
dc.identifier.issn0378-1119en_US
dc.identifier.urihttp://hdl.handle.net/10722/178643-
dc.description.abstractgClqBP is a novel cell protein which was found to interact with the globular heads of Clq, high mol. wt kininogen, factor XII and the heparin-binding, multimeric form of vitronectin. The protein sequence shows no homology to any protein family. This paper describes the genomic organization of mouse gClqBP and the characterization of its 5' flanking region. The mouse gene consists of six exons separated by five introns, and its total length is approximately 6 kb. Exon 1 encodes the putative signal peptide, a long stretch of 70 amino acid residues, and the first four amino acid residues found in the mature gClqBP. Exons 2-5 encode four very hydrophilic domains, whereas exon 6 encodes a neutral domain. The amino acid sequence responsible for binding to the heparin-binding, multimeric form of vitronectin is located in exon 2. A 1 kb DNA fragment upstream of the first initiation codon was sequenced, which contained four potential TATA boxes, seven CAAT boxes, six SP1 sites and various putative transcription factor-binding elements, indicating that the promoter region is in close proximity to the first exon. The mouse Clqbp gene was mapped to chromosome 11, closely linked to D11Mit4 using genomic DNAs from a (C57BL/6J x Mus spretus)F1 x Mus spretus backcross.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/geneen_US
dc.relation.ispartofGeneen_US
dc.rightsGene. Copyright © Elsevier BV.-
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Cd44en_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshComplement C1q - Chemistry - Metabolismen_US
dc.subject.meshCrosses, Geneticen_US
dc.subject.meshExonsen_US
dc.subject.meshFactor Xii - Chemistry - Metabolismen_US
dc.subject.meshGenomic Libraryen_US
dc.subject.meshIntronsen_US
dc.subject.meshKininogen, High-Molecular-Weight - Chemistry - Metabolismen_US
dc.subject.meshMembrane Glycoproteinsen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57bl - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshMuridae - Geneticsen_US
dc.subject.meshOligonucleotide Probesen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshReceptors, Complement - Genetics - Metabolismen_US
dc.subject.meshRegulatory Sequences, Nucleic Aciden_US
dc.subject.meshRestriction Mappingen_US
dc.subject.meshVitronectin - Chemistry - Metabolismen_US
dc.titleCharacterization of the murine gene of gClqBP, a novel cell protein that binds the globular heads of Clq, vitronectin, high molecular weight kininogen and factor XIIen_US
dc.typeArticleen_US
dc.identifier.emailLim, BL: bllim@hkucc.hku.hken_US
dc.identifier.authorityLim, BL=rp00744en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0378-1119(98)00055-9en_US
dc.identifier.pmid9524273-
dc.identifier.scopuseid_2-s2.0-0032536885en_US
dc.identifier.hkuros34156-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032536885&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume209en_US
dc.identifier.issue1-2en_US
dc.identifier.spage229en_US
dc.identifier.epage237en_US
dc.identifier.isiWOS:000072941100028-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLim, BL=7201983917en_US
dc.identifier.scopusauthoridWhite, RA=15753174400en_US
dc.identifier.scopusauthoridHummel, GS=7005529558en_US
dc.identifier.scopusauthoridSchwaeble, W=7005335401en_US
dc.identifier.scopusauthoridMak, SC=7102103297en_US
dc.identifier.scopusauthoridPeerschke, EIB=7005991940en_US
dc.identifier.scopusauthoridReid, KBM=7202780648en_US
dc.identifier.scopusauthoridGhebrehiwet, B=7005039582en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats