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Article: The effect of tert-butyl hydroperoxide on peritoneal macrophages and the protective effect of protein-bound polysaccharide administered intraperitoneally and orally

TitleThe effect of tert-butyl hydroperoxide on peritoneal macrophages and the protective effect of protein-bound polysaccharide administered intraperitoneally and orally
Authors
Issue Date1998
PublisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtml
Citation
American Journal Of Chinese Medicine, 1998, v. 26 n. 3-4, p. 301-310 How to Cite?
AbstractOur previous studies have shown that a protein-bound polysaccharide, polysaccharide krestin (PSK), can protect macrophages from lipoperoxidative injury induced by tert-butyl hydroperoxide (tbOOH) and oxidatively modified low density lipoprotein (O-LDL). PSK was administered intraperitoneally to mice, and the peritoneal macrophages harvested were used as an experimental model. PSK does not reveal any protective effect on macrophages injured by tbOOH when incubated in vitro. In order to elucidate its mode of action, in the present study, the protective effects of PSK were further investigated using morphological changes and viability as indices. It was shown that, compared with the non-PSK group, the viability of macrophages was much higher in the PSK group, and the morphological changes in the PSK group were much less than those in the non-PSK group. The protective effect of PSK administered intraperitoneally and orally on macrophages injured by tbOOH was comparable. Furthermore, the serum of the PSK treated mice had the same protective effect. © 1998 Institute for Advanced Research in Asian Science and Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/178635
ISSN
2015 Impact Factor: 2.959
2015 SCImago Journal Rankings: 0.797
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Men_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorOuyang, Qen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorPang, ZJen_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:50Z-
dc.date.available2012-12-19T09:48:50Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Chinese Medicine, 1998, v. 26 n. 3-4, p. 301-310en_US
dc.identifier.issn0192-415Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/178635-
dc.description.abstractOur previous studies have shown that a protein-bound polysaccharide, polysaccharide krestin (PSK), can protect macrophages from lipoperoxidative injury induced by tert-butyl hydroperoxide (tbOOH) and oxidatively modified low density lipoprotein (O-LDL). PSK was administered intraperitoneally to mice, and the peritoneal macrophages harvested were used as an experimental model. PSK does not reveal any protective effect on macrophages injured by tbOOH when incubated in vitro. In order to elucidate its mode of action, in the present study, the protective effects of PSK were further investigated using morphological changes and viability as indices. It was shown that, compared with the non-PSK group, the viability of macrophages was much higher in the PSK group, and the morphological changes in the PSK group were much less than those in the non-PSK group. The protective effect of PSK administered intraperitoneally and orally on macrophages injured by tbOOH was comparable. Furthermore, the serum of the PSK treated mice had the same protective effect. © 1998 Institute for Advanced Research in Asian Science and Medicine.en_US
dc.languageengen_US
dc.publisherWorld Scientific Publishing Co Pte Ltd. The Journal's web site is located at http://www.worldscinet.com/ajcm/ajcm.shtmlen_US
dc.relation.ispartofAmerican Journal of Chinese Medicineen_US
dc.titleThe effect of tert-butyl hydroperoxide on peritoneal macrophages and the protective effect of protein-bound polysaccharide administered intraperitoneally and orallyen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0032240278en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032240278&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume26en_US
dc.identifier.issue3-4en_US
dc.identifier.spage301en_US
dc.identifier.epage310en_US
dc.publisher.placeSingaporeen_US
dc.identifier.scopusauthoridZhou, M=35118437000en_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridOuyang, Q=7101796656en_US
dc.identifier.scopusauthoridLiu, S=7409463469en_US
dc.identifier.scopusauthoridPang, ZJ=7103343225en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US

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