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Article: Oxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells

TitleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cells
Authors
Issue Date1998
PublisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journal
Citation
British Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198 How to Cite?
AbstractComparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other.
Persistent Identifierhttp://hdl.handle.net/10722/178620
ISSN
2015 Impact Factor: 1.245
2015 SCImago Journal Rankings: 0.352
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhou, Men_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorLiu, Sen_US
dc.contributor.authorDing, Zen_US
dc.contributor.authorPang, Zen_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:45Z-
dc.date.available2012-12-19T09:48:45Z-
dc.date.issued1998en_US
dc.identifier.citationBritish Journal Of Biomedical Science, 1998, v. 55 n. 3, p. 192-198en_US
dc.identifier.issn0967-4845en_US
dc.identifier.urihttp://hdl.handle.net/10722/178620-
dc.description.abstractComparative study of oxidatively modified low-density lipoprotein (Ox-LDL) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) is important for further understanding the biological properties of Ox-LDL, such as its toxic effects, immunogenicity and multiplicity of scavenger receptor binding. In this study, the characteristics of Ox-LDL and MDA-LDL binding and degradation were compared. The results show that when their degree of modification (as determined by relative electrophoretic mobility) was similar, the binding and degradation of Ox-LDL by the macrophage cell line P388D1 were greater than those of MDA-LDL. The binding and degradation of Ox-LDL by macrophages and human umbilical vein endothelial cells increased with the degree of modification. In addition, Ox-LDL or MDA-LDL could competitively inhibit binding of labelled Ox-LDL or labelled MDA-LDL to their respective macrophage receptors, and could partially inhibit each other.en_US
dc.languageengen_US
dc.publisherStep Communications Ltd. The Journal's web site is located at http://www.ibms.org/index.cfm?method=publications.british_journalen_US
dc.relation.ispartofBritish Journal of Biomedical Scienceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Culture Techniquesen_US
dc.subject.meshEndothelium, Vascular - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLipoproteins, Ldl - Metabolismen_US
dc.subject.meshMacrophages, Peritoneal - Metabolismen_US
dc.subject.meshMalondialdehyde - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshOxidation-Reductionen_US
dc.titleOxidative and malondialdehyde modification of low-density lipoprotein: A comparative study of binding and degradation by macrophages and endothelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10367404-
dc.identifier.scopuseid_2-s2.0-0031756156en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031756156&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume55en_US
dc.identifier.issue3en_US
dc.identifier.spage192en_US
dc.identifier.epage198en_US
dc.identifier.isiWOS:000076519700006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhou, M=7403506134en_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridLiu, S=7409463469en_US
dc.identifier.scopusauthoridDing, Z=35247593000en_US
dc.identifier.scopusauthoridPang, Z=7103343225en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US

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