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Article: Protective effect of the polysaccharide kreskin on inhibition of lipopolysaccharide-induced nitric oxide production in macrophages caused by oxidised low-density lipoprotein

TitleProtective effect of the polysaccharide kreskin on inhibition of lipopolysaccharide-induced nitric oxide production in macrophages caused by oxidised low-density lipoprotein
Authors
KeywordsKreskin
Lipopolysaccharide
Nitric Oxide
Nitric Oxide Synthase
Oxidised Low Density Lipoprotein
Peritoneal Macrophage
Polysaccharide
Issue Date1997
PublisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.html
Citation
Medical Science Research, 1997, v. 25 n. 8, p. 507-509 How to Cite?
AbstractWe studied the inhibition by oxidised low-density lipoprotein (Ox-LDL) of the production of NO and gene expression of NO synthase (NOS) in mouse peritoneal macrophages stimulated by lipopolysaccharide (LPS), and protection by the polysaccharide kreskin (PSK). This was done by measuring nitrite in media and messenger RNA(mRNA) for NOS in macrophages. Exposure of mouse peritoneal macrophages (MPM) to Ox-LDL inhibited NO production stimulated by LPS, but exposure of MPM to native LDL and acetylated LDL did not do so. PSK, injected peritoneally into mice, protected their macrophages from the inhibition of NO production caused by Ox-LDL. Results from slot hybridisation showed that Ox-LDL lowered the content of mRNA for NOS in macrophages induced by LPS, while PSK protected macrophages from the decline of mRNA in macrophages caused by Ox-LDL.
Persistent Identifierhttp://hdl.handle.net/10722/178604
ISSN
2001 Impact Factor: 0.384
2003 SCImago Journal Rankings: 0.107
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, SXen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorZhou, Men_US
dc.contributor.authorWan, Jen_US
dc.date.accessioned2012-12-19T09:48:38Z-
dc.date.available2012-12-19T09:48:38Z-
dc.date.issued1997en_US
dc.identifier.citationMedical Science Research, 1997, v. 25 n. 8, p. 507-509en_US
dc.identifier.issn0269-8951en_US
dc.identifier.urihttp://hdl.handle.net/10722/178604-
dc.description.abstractWe studied the inhibition by oxidised low-density lipoprotein (Ox-LDL) of the production of NO and gene expression of NO synthase (NOS) in mouse peritoneal macrophages stimulated by lipopolysaccharide (LPS), and protection by the polysaccharide kreskin (PSK). This was done by measuring nitrite in media and messenger RNA(mRNA) for NOS in macrophages. Exposure of mouse peritoneal macrophages (MPM) to Ox-LDL inhibited NO production stimulated by LPS, but exposure of MPM to native LDL and acetylated LDL did not do so. PSK, injected peritoneally into mice, protected their macrophages from the inhibition of NO production caused by Ox-LDL. Results from slot hybridisation showed that Ox-LDL lowered the content of mRNA for NOS in macrophages induced by LPS, while PSK protected macrophages from the decline of mRNA in macrophages caused by Ox-LDL.en_US
dc.languageengen_US
dc.publisherChapman & Hall, Journals Department. The Journal's web site is located at http://www.chaphall.com/chaphall/journals.htmlen_US
dc.relation.ispartofMedical Science Researchen_US
dc.subjectKreskinen_US
dc.subjectLipopolysaccharideen_US
dc.subjectNitric Oxideen_US
dc.subjectNitric Oxide Synthaseen_US
dc.subjectOxidised Low Density Lipoproteinen_US
dc.subjectPeritoneal Macrophageen_US
dc.subjectPolysaccharideen_US
dc.titleProtective effect of the polysaccharide kreskin on inhibition of lipopolysaccharide-induced nitric oxide production in macrophages caused by oxidised low-density lipoproteinen_US
dc.typeArticleen_US
dc.identifier.emailWan, J: jmfwan@hku.hken_US
dc.identifier.authorityWan, J=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-0030862841en_US
dc.identifier.hkuros35646-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030862841&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue8en_US
dc.identifier.spage507en_US
dc.identifier.epage509en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLiu, SX=7409463469en_US
dc.identifier.scopusauthoridChen, Y=16745998900en_US
dc.identifier.scopusauthoridZhou, M=7403506134en_US
dc.identifier.scopusauthoridWan, J=8930305000en_US

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