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Article: Interactions of somatostatin, gonadotropin-releasing hormone, and the gonads on dopamine-stimulated growth hormone release in the goldfish

TitleInteractions of somatostatin, gonadotropin-releasing hormone, and the gonads on dopamine-stimulated growth hormone release in the goldfish
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcen
Citation
General And Comparative Endocrinology, 1993, v. 92 n. 3, p. 366-378 How to Cite?
AbstractPreviously, we have demonstrated that dopamine (DA) stimulates growth hormone (GH) release from the goldfish pituitary through DA D1 receptors. In the present study, the role of DA as a GH-releasing factor was further examined in vitro by studying its interactions with other GH regulators in the goldfish. The GH-releasing effects of DA and salmon gonadotropin- releasing hormone (sGnRH) were found to be independent and additive at the pituitary cell level. Both the kinetics and the magnitude of DA-stimulated GH release were unaffected by simultaneous treatment with sGnRH and vice versa. Castration of sexually mature (or prespawning) goldfish significantly enhanced the DA-stimulated GH release, but at the same time reduced the GH responses to sGnRH. Furthermore, the GH responses to DA and the D1 agonist SKF38393 were totally abolished by somatostatin (SRIF), a known GH release inhibitor in the goldfish. These findings strongly indicate that SRIF, DA, sGnRH, and gonadal factors interact at the pituitary level to regulate GH release in the goldfish.
Persistent Identifierhttp://hdl.handle.net/10722/178557
ISSN
2015 Impact Factor: 2.667
2015 SCImago Journal Rankings: 1.245
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, AOLen_US
dc.contributor.authorChang, JPen_US
dc.contributor.authorPeter, REen_US
dc.date.accessioned2012-12-19T09:48:22Z-
dc.date.available2012-12-19T09:48:22Z-
dc.date.issued1993en_US
dc.identifier.citationGeneral And Comparative Endocrinology, 1993, v. 92 n. 3, p. 366-378en_US
dc.identifier.issn0016-6480en_US
dc.identifier.urihttp://hdl.handle.net/10722/178557-
dc.description.abstractPreviously, we have demonstrated that dopamine (DA) stimulates growth hormone (GH) release from the goldfish pituitary through DA D1 receptors. In the present study, the role of DA as a GH-releasing factor was further examined in vitro by studying its interactions with other GH regulators in the goldfish. The GH-releasing effects of DA and salmon gonadotropin- releasing hormone (sGnRH) were found to be independent and additive at the pituitary cell level. Both the kinetics and the magnitude of DA-stimulated GH release were unaffected by simultaneous treatment with sGnRH and vice versa. Castration of sexually mature (or prespawning) goldfish significantly enhanced the DA-stimulated GH release, but at the same time reduced the GH responses to sGnRH. Furthermore, the GH responses to DA and the D1 agonist SKF38393 were totally abolished by somatostatin (SRIF), a known GH release inhibitor in the goldfish. These findings strongly indicate that SRIF, DA, sGnRH, and gonadal factors interact at the pituitary level to regulate GH release in the goldfish.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygcenen_US
dc.relation.ispartofGeneral and Comparative Endocrinologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDopamine - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGoldfish - Metabolismen_US
dc.subject.meshGonadotropin-Releasing Hormone - Metabolismen_US
dc.subject.meshGonadotropins, Pituitary - Secretionen_US
dc.subject.meshGonads - Metabolism - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshOrchiectomyen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshPerfusionen_US
dc.subject.meshPituitary Gland - Cytology - Physiologyen_US
dc.subject.meshSomatostatin - Metabolism - Secretionen_US
dc.titleInteractions of somatostatin, gonadotropin-releasing hormone, and the gonads on dopamine-stimulated growth hormone release in the goldfishen_US
dc.typeArticleen_US
dc.identifier.emailWong, AOL: olwong@hkucc.hku.hken_US
dc.identifier.authorityWong, AOL=rp00806en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/gcen.1993.1174en_US
dc.identifier.pmid7907999-
dc.identifier.scopuseid_2-s2.0-0027731502en_US
dc.identifier.volume92en_US
dc.identifier.issue3en_US
dc.identifier.spage366en_US
dc.identifier.epage378en_US
dc.identifier.isiWOS:A1993MP21100005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, AOL=7403147570en_US
dc.identifier.scopusauthoridChang, JP=7601547649en_US
dc.identifier.scopusauthoridPeter, RE=7202909690en_US

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