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Article: Buspirone-induced carbohydrate feeding is not influenced by route of administration and nutritional status

TitleBuspirone-induced carbohydrate feeding is not influenced by route of administration and nutritional status
Authors
Issue Date1993
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/brainresbull
Citation
Brain Research Bulletin, 1993, v. 30 n. 5-6, p. 547-550 How to Cite?
AbstractRats were habituated to ad lib food intake from two isoenergetic diets that differed in carbohydrate and protein content. To examine the route of administration effect, buspirone (0.6, 1.0, and 1.4 mg/kg) was injected into satiated rats either subcutaneously or intraperitoneally. Overall, no route of administration effect was observed; however, when results of the lowest dose were analyzed separately, the subcutaneous route was more effective than the intraperitoneal route. Regardless of route of administration, buspirone increased food intake over the first 2 h of food presentation in a dose- dependent manner. Moreover, the increase was entirely attributed to increases in intake from the high carbohydrate diet. In the subsequent experiment, the effect of buspirone (0.6 mg/kg) was examined in both satiated (early light period) and nonsatiated rats (early dark period). Both groups responded to buspirone with an increase in carbohydrate intake. Despite differences in baseline intake, the absolute increase was similar between satiated and nonsatiated rats. These data suggest that both sensitivity and selectivity of buspirone-induced feeding are neither influenced by route of administration nor nutritional status of rats.
Persistent Identifierhttp://hdl.handle.net/10722/178550
ISSN
2015 Impact Factor: 2.572
2015 SCImago Journal Rankings: 1.410
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, ETSen_US
dc.contributor.authorLuo, Sen_US
dc.date.accessioned2012-12-19T09:48:19Z-
dc.date.available2012-12-19T09:48:19Z-
dc.date.issued1993en_US
dc.identifier.citationBrain Research Bulletin, 1993, v. 30 n. 5-6, p. 547-550en_US
dc.identifier.issn0361-9230en_US
dc.identifier.urihttp://hdl.handle.net/10722/178550-
dc.description.abstractRats were habituated to ad lib food intake from two isoenergetic diets that differed in carbohydrate and protein content. To examine the route of administration effect, buspirone (0.6, 1.0, and 1.4 mg/kg) was injected into satiated rats either subcutaneously or intraperitoneally. Overall, no route of administration effect was observed; however, when results of the lowest dose were analyzed separately, the subcutaneous route was more effective than the intraperitoneal route. Regardless of route of administration, buspirone increased food intake over the first 2 h of food presentation in a dose- dependent manner. Moreover, the increase was entirely attributed to increases in intake from the high carbohydrate diet. In the subsequent experiment, the effect of buspirone (0.6 mg/kg) was examined in both satiated (early light period) and nonsatiated rats (early dark period). Both groups responded to buspirone with an increase in carbohydrate intake. Despite differences in baseline intake, the absolute increase was similar between satiated and nonsatiated rats. These data suggest that both sensitivity and selectivity of buspirone-induced feeding are neither influenced by route of administration nor nutritional status of rats.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/brainresbullen_US
dc.relation.ispartofBrain Research Bulletinen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBuspirone - Administration & Dosage - Pharmacologyen_US
dc.subject.meshDietary Carbohydrates - Administration & Dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrinking - Drug Effectsen_US
dc.subject.meshEating - Drug Effectsen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshMaleen_US
dc.subject.meshNutritional Status - Physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSatiety Response - Drug Effectsen_US
dc.titleBuspirone-induced carbohydrate feeding is not influenced by route of administration and nutritional statusen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8457904-
dc.identifier.scopuseid_2-s2.0-0027406139en_US
dc.identifier.volume30en_US
dc.identifier.issue5-6en_US
dc.identifier.spage547en_US
dc.identifier.epage550en_US
dc.identifier.isiWOS:A1993KQ56800004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US
dc.identifier.scopusauthoridLuo, S=16151581100en_US

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