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Article: Influence of ω-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model

TitleInfluence of ω-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat model
Authors
Issue Date1992
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 1992, v. 41 n. 7, p. 698-705 How to Cite?
AbstractAlteration in regional blood flow is important in the pathogenesis of organ failure during endotoxemia and sepsis. In particular, intestinal ischemia is thought to enhance the translocation of bacteria into the systemic circulation. We used radioactive microspheres to measure the influence of two intravenous (IV) dietary fats (vegetable oil containing high levels of ω-6 fatty acids, and fish oil containing high levels of ω-3 fatty acids) on regional blood flow during low-dose Escherichia coli endotoxin infusion (0.1 mg/100 g body weight [BW]) in a rat model. Despite absence of changes in the cardiac output, blood flow rates to the small and large intestines, stomach, and pancreas, and also to the skin and skeletal muscle were significantly reduced after 18 hours of endotoxin infusion in the rats fed standard vegetable oil. Short-term IV feeding during a period of 40 hours with an isonitrogenous, isocaloric nutrient solution containing fish oil as the only lipid source normalized intestinal perfusion and increased blood flow to the liver and spleen. Low-dose endotoxin infusion also resulted in significant increases in glucose, lactate, and pyruvate concentrations. In comparison to standard vegetable fat emulsion, fish oil significantly reduced these parameters. A second experiment was conducted to measure lactate kinetics. Based on the dilution of U-14C-lactate, fish oil feeding was associated with higher lactate clearance than standard vegetable oil feeding during the endotoxin infusion. We conclude that short-term IV feeding with fish oil improves intestinal perfusion and portal blood flow, improves glucose tolerance, and increases lactate clearance in a low-dose endotoxin rat model.
Persistent Identifierhttp://hdl.handle.net/10722/178529
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPscheidl, EMen_US
dc.contributor.authorWan, JMen_US
dc.contributor.authorBlackburn, GLen_US
dc.contributor.authorBistrian, BRen_US
dc.contributor.authorIstfan, NWen_US
dc.date.accessioned2012-12-19T09:48:14Z-
dc.date.available2012-12-19T09:48:14Z-
dc.date.issued1992en_US
dc.identifier.citationMetabolism: Clinical And Experimental, 1992, v. 41 n. 7, p. 698-705en_US
dc.identifier.issn0026-0495en_US
dc.identifier.urihttp://hdl.handle.net/10722/178529-
dc.description.abstractAlteration in regional blood flow is important in the pathogenesis of organ failure during endotoxemia and sepsis. In particular, intestinal ischemia is thought to enhance the translocation of bacteria into the systemic circulation. We used radioactive microspheres to measure the influence of two intravenous (IV) dietary fats (vegetable oil containing high levels of ω-6 fatty acids, and fish oil containing high levels of ω-3 fatty acids) on regional blood flow during low-dose Escherichia coli endotoxin infusion (0.1 mg/100 g body weight [BW]) in a rat model. Despite absence of changes in the cardiac output, blood flow rates to the small and large intestines, stomach, and pancreas, and also to the skin and skeletal muscle were significantly reduced after 18 hours of endotoxin infusion in the rats fed standard vegetable oil. Short-term IV feeding during a period of 40 hours with an isonitrogenous, isocaloric nutrient solution containing fish oil as the only lipid source normalized intestinal perfusion and increased blood flow to the liver and spleen. Low-dose endotoxin infusion also resulted in significant increases in glucose, lactate, and pyruvate concentrations. In comparison to standard vegetable fat emulsion, fish oil significantly reduced these parameters. A second experiment was conducted to measure lactate kinetics. Based on the dilution of U-14C-lactate, fish oil feeding was associated with higher lactate clearance than standard vegetable oil feeding during the endotoxin infusion. We conclude that short-term IV feeding with fish oil improves intestinal perfusion and portal blood flow, improves glucose tolerance, and increases lactate clearance in a low-dose endotoxin rat model.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_US
dc.relation.ispartofMetabolism: Clinical and Experimentalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCardiac Output - Drug Effectsen_US
dc.subject.meshEndotoxins - Toxicityen_US
dc.subject.meshFatty Acids, Omega-3 - Pharmacologyen_US
dc.subject.meshFish Oils - Pharmacologyen_US
dc.subject.meshGlucose - Metabolismen_US
dc.subject.meshLactates - Metabolismen_US
dc.subject.meshLactic Aciden_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshSplanchnic Circulation - Drug Effectsen_US
dc.subject.meshThromboxane A2 - Physiologyen_US
dc.subject.meshToxemia - Physiopathologyen_US
dc.titleInfluence of ω-3 fatty acids on splanchnic blood flow and lactate metabolism in an endotoxemic rat modelen_US
dc.typeArticleen_US
dc.identifier.emailWan, JM: jmfwan@hku.hken_US
dc.identifier.authorityWan, JM=rp00798en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0026-0495(92)90307-Ven_US
dc.identifier.pmid1619987-
dc.identifier.scopuseid_2-s2.0-0026643956en_US
dc.identifier.volume41en_US
dc.identifier.issue7en_US
dc.identifier.spage698en_US
dc.identifier.epage705en_US
dc.identifier.isiWOS:A1992JB35500005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridPscheidl, EM=6603846310en_US
dc.identifier.scopusauthoridWan, JM=8930305000en_US
dc.identifier.scopusauthoridBlackburn, GL=7201722807en_US
dc.identifier.scopusauthoridBistrian, BR=35463916700en_US
dc.identifier.scopusauthoridIstfan, NW=7003819779en_US

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