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Article: Effect of 5-HT agonists on rats fed single diets with varying proportions of carbohydrate and protein

TitleEffect of 5-HT agonists on rats fed single diets with varying proportions of carbohydrate and protein
Authors
Issue Date1992
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htm
Citation
Psychopharmacology, 1992, v. 109 n. 1-2, p. 212-216 How to Cite?
AbstractLow doses of 5-HT agonists have been shown to selectively suppress carbohydrate intake in rats given dietary choices. To investigate further the relationship between dietary macronutrient composition and 5-HT-induced anorexia, the present study examined the effects of three 5-HT agonists on rats fed single isocaloric diets containing varying proportions of carbohydrate (CHO) and protein (PRO). Rats were habituated to eat one of the three diets (73.5% CHO - 10% PRO, 58.5% CHO - 25% PRO or 43.5% CHO - 40% PRO) during the dark period (1900-0700 h). Saline or 5-HT agonists (fluoxetine, RU 24969 and dexfenfluramine) were administered intraperitoneally at 1845 hours, 15 min prior to food access. At the doses used, food intake was significantly affected only during the first hour of eating. All 5-HT agonists caused dose-dependent decreases in food intake (P < 0.01). The magnitude of decrease, however, was significantly influenced by diet composition. Reduction in intake was greatest in rats fed the 73.5% CHO - 10% PRO diet. Thus, rats chronically fed a diet high in carbohydrate content were more sensitive to the anorectic effect of 5-HT agonists than rats fed diets containing moderate to low levels of carbohydrate.
Persistent Identifierhttp://hdl.handle.net/10722/178523
ISSN
2015 Impact Factor: 3.54
2015 SCImago Journal Rankings: 1.687
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Sen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2012-12-19T09:48:12Z-
dc.date.available2012-12-19T09:48:12Z-
dc.date.issued1992en_US
dc.identifier.citationPsychopharmacology, 1992, v. 109 n. 1-2, p. 212-216en_US
dc.identifier.issn0033-3158en_US
dc.identifier.urihttp://hdl.handle.net/10722/178523-
dc.description.abstractLow doses of 5-HT agonists have been shown to selectively suppress carbohydrate intake in rats given dietary choices. To investigate further the relationship between dietary macronutrient composition and 5-HT-induced anorexia, the present study examined the effects of three 5-HT agonists on rats fed single isocaloric diets containing varying proportions of carbohydrate (CHO) and protein (PRO). Rats were habituated to eat one of the three diets (73.5% CHO - 10% PRO, 58.5% CHO - 25% PRO or 43.5% CHO - 40% PRO) during the dark period (1900-0700 h). Saline or 5-HT agonists (fluoxetine, RU 24969 and dexfenfluramine) were administered intraperitoneally at 1845 hours, 15 min prior to food access. At the doses used, food intake was significantly affected only during the first hour of eating. All 5-HT agonists caused dose-dependent decreases in food intake (P < 0.01). The magnitude of decrease, however, was significantly influenced by diet composition. Reduction in intake was greatest in rats fed the 73.5% CHO - 10% PRO diet. Thus, rats chronically fed a diet high in carbohydrate content were more sensitive to the anorectic effect of 5-HT agonists than rats fed diets containing moderate to low levels of carbohydrate.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00213/index.htmen_US
dc.relation.ispartofPsychopharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDietary Carbohydrates - Pharmacologyen_US
dc.subject.meshDietary Proteins - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEating - Drug Effectsen_US
dc.subject.meshFenfluramine - Pharmacologyen_US
dc.subject.meshFluoxetine - Pharmacologyen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSerotonin Receptor Agonists - Pharmacologyen_US
dc.titleEffect of 5-HT agonists on rats fed single diets with varying proportions of carbohydrate and proteinen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02245502en_US
dc.identifier.pmid1365659-
dc.identifier.scopuseid_2-s2.0-0026452186en_US
dc.identifier.volume109en_US
dc.identifier.issue1-2en_US
dc.identifier.spage212en_US
dc.identifier.epage216en_US
dc.identifier.isiWOS:A1992JQ59200028-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridLuo, S=16151581100en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US

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