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Article: Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats

TitleEffects of repeated administration of serotonergic agonists on diet selection and body weight in rats
Authors
Issue Date1991
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 1991, v. 38 n. 3, p. 495-500 How to Cite?
AbstractFood intake, diet selection and body weight gain were examined in three separate experiments in which rats received saline or one of three serotonergic agonists, dexfenfluramine, RU 24969 and fluoxetine. In all experiments, food was available only in the dark period during which time rats were given simultaneous access to two isoenergetic diets which differed in their protein and carbohydrate content. After habituation to this feeding paradigm and intraperitoneal injections, rats were assigned to control or drug group. Saline or a serotonergic agonist was given to the same rat once daily, 15 min prior to feeding, for six consecutive days. All three agonists (1.5 mg/kg for dexfenfluramine and RU 24969; 3 mg/kg for fluoxetine) caused immediate (first two h of feeding) hypophagia which was accounted for by the selective suppression in intake of the high-carbohydrate-low-protein diet. This selective shift in diet choice was sustained upon repeated exposure. Although the effects of these agonists on daily (12-h) feeding was less pronounced, appetite suppression was due entirely to reduced intake of the high-carbohydrate-low-protein diet. Of the three agonists tested, partial tolerance was observed only after dexfenfluramine. Nevertheless, all three agonists caused comparable declines in weight gain. These results suggest that repeated administration of serotonergic agonists has sustained impacts on food intake, diet choice and weight gain.
Persistent Identifierhttp://hdl.handle.net/10722/178510
ISSN
2015 Impact Factor: 2.537
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Sen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2012-12-19T09:48:07Z-
dc.date.available2012-12-19T09:48:07Z-
dc.date.issued1991en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 1991, v. 38 n. 3, p. 495-500en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/178510-
dc.description.abstractFood intake, diet selection and body weight gain were examined in three separate experiments in which rats received saline or one of three serotonergic agonists, dexfenfluramine, RU 24969 and fluoxetine. In all experiments, food was available only in the dark period during which time rats were given simultaneous access to two isoenergetic diets which differed in their protein and carbohydrate content. After habituation to this feeding paradigm and intraperitoneal injections, rats were assigned to control or drug group. Saline or a serotonergic agonist was given to the same rat once daily, 15 min prior to feeding, for six consecutive days. All three agonists (1.5 mg/kg for dexfenfluramine and RU 24969; 3 mg/kg for fluoxetine) caused immediate (first two h of feeding) hypophagia which was accounted for by the selective suppression in intake of the high-carbohydrate-low-protein diet. This selective shift in diet choice was sustained upon repeated exposure. Although the effects of these agonists on daily (12-h) feeding was less pronounced, appetite suppression was due entirely to reduced intake of the high-carbohydrate-low-protein diet. Of the three agonists tested, partial tolerance was observed only after dexfenfluramine. Nevertheless, all three agonists caused comparable declines in weight gain. These results suggest that repeated administration of serotonergic agonists has sustained impacts on food intake, diet choice and weight gain.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weight - Drug Effectsen_US
dc.subject.meshDieten_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFenfluramine - Pharmacologyen_US
dc.subject.meshFluoxetine - Pharmacologyen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Serotonin - Drug Effectsen_US
dc.titleEffects of repeated administration of serotonergic agonists on diet selection and body weight in ratsen_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0091-3057(91)90003-Ken_US
dc.identifier.pmid2068186-
dc.identifier.scopuseid_2-s2.0-0025967381en_US
dc.identifier.volume38en_US
dc.identifier.issue3en_US
dc.identifier.spage495en_US
dc.identifier.epage500en_US
dc.identifier.isiWOS:A1991FD88800003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuo, S=16151581100en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US

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