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Article: Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969

TitleFood intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969
Authors
Issue Date1990
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/brainresbull
Citation
Brain Research Bulletin, 1990, v. 24 n. 6, p. 729-733 How to Cite?
AbstractThe effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intraperitoneally at 1845 hr, 15 min prior to food access. The drugs exerted their effects mainly during the first hour of feeding (1900-2000 hr). At this time, a selective suppression in intake of the high carbohydrate-low protein diet was the most prominent characteristic of all three serotonergic agonists. This macronutrient specific effect was particularly strong at low dosages (dexfenfluramine, fluoxetine and RU 24969: 0.5, 2.0 and 1.0 mg/kg, respectively). With time, as the effect of drugs wore off, diet selection pattern became more variable. The fact that both indirect 5-HT agonists and a direct selective 5-HT receptor agonist share a specific behavioral effect provides additional support for the role of serotonin in the control of macronutrient specific appetites.
Persistent Identifierhttp://hdl.handle.net/10722/178491
ISSN
2015 Impact Factor: 2.572
2015 SCImago Journal Rankings: 1.410
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, Sen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2012-12-19T09:48:00Z-
dc.date.available2012-12-19T09:48:00Z-
dc.date.issued1990en_US
dc.identifier.citationBrain Research Bulletin, 1990, v. 24 n. 6, p. 729-733en_US
dc.identifier.issn0361-9230en_US
dc.identifier.urihttp://hdl.handle.net/10722/178491-
dc.description.abstractThe effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intraperitoneally at 1845 hr, 15 min prior to food access. The drugs exerted their effects mainly during the first hour of feeding (1900-2000 hr). At this time, a selective suppression in intake of the high carbohydrate-low protein diet was the most prominent characteristic of all three serotonergic agonists. This macronutrient specific effect was particularly strong at low dosages (dexfenfluramine, fluoxetine and RU 24969: 0.5, 2.0 and 1.0 mg/kg, respectively). With time, as the effect of drugs wore off, diet selection pattern became more variable. The fact that both indirect 5-HT agonists and a direct selective 5-HT receptor agonist share a specific behavioral effect provides additional support for the role of serotonin in the control of macronutrient specific appetites.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/brainresbullen_US
dc.relation.ispartofBrain Research Bulletinen_US
dc.subject.meshAnimalsen_US
dc.subject.meshFeeding Behavior - Drug Effectsen_US
dc.subject.meshFenfluramine - Pharmacologyen_US
dc.subject.meshFluoxetine - Pharmacologyen_US
dc.subject.meshIndoles - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshReceptors, Serotonin - Drug Effectsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.titleFood intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969en_US
dc.typeArticleen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0361-9230(90)90130-Ren_US
dc.identifier.pmid2372690-
dc.identifier.scopuseid_2-s2.0-0025285884en_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage729en_US
dc.identifier.epage733en_US
dc.identifier.isiWOS:A1990DJ79300004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLuo, S=16151581100en_US
dc.identifier.scopusauthoridLi, ETS=14018169600en_US

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